Myositis Ossificans Traumatica With Unusual Course Effect of Edta on Calcium, Phosphorus and Manganese Excretion

Metabolic and calcium kinetic studies in idiopathic hypercalciuria

“…The metabolic balance period extending over 7-10 days was started after 3-5 days of adaptation to the metabolic ward routine. The procedure of collection of excreta and the methods for calcium and phosphorus determination in serum, urine, and feces were as described elsewhere (18).…”

“…Radioactivity of urinary calcium was measured either directly on 3-ml urine samples taken from the 24 hr collections, or on 50-ml samples of urine from which the calcium was precipitated as oxalate and redissolved in 3 ml of hot 70% perchloric acid. The content of '0Ca (stable calcium) of the samples used for measuring radioactivity was determined by flame spectrophotometry as described elsewhere (18) and the specific activity, expressed as per cent of the injected dose per gram of calcium, was calculated accordingly. The radioactivity of the pooled stools was determined either directly on 3 g of stool homogenate or on 3 g of ashed stool prepared from 50 g of homogenate dissolved in 3 ml of hot 0.5 N hydrochloric acid.…”

Elevated vitamin D receptor levels in genetic hypercalciuric stone-forming rats are associated with downregulation of Snail

“…Idiopathic hypercalciuria (IH) is found in 5% to 7% of the adult population and is the most common risk factor for calcium (Ca) oxalate (Ox) nephrolithiasis 1. Hypercalciuria is thought to play an important role in the pathogenesis of CaOx stone formation through increased urine supersaturation with respect to Ca and Ox 1–4. The disease is characterized by high intestinal Ca absorption and bone resorption and decreased renal Ca reabsorption resulting in hypercalciuria with normal serum Ca, normal or elevated serum 1,25‐dihydroxyvitamin D [1,25(OH) 2 D], normal or low serum phosphate, and low bone mass 1, 4–10.…”

“…(1) Hypercalciuria is thought to play an important role in the pathogenesis of CaOx stone formation through increased urine supersaturation with respect to Ca and Ox. (1)(2)(3)(4) The disease is characterized by high intestinal Ca absorption and bone resorption and decreased renal Ca reabsorption resulting in hypercalciuria with normal serum Ca, normal or elevated serum 1,25-dihydroxyvitamin D [1,25(OH) 2 D], normal or low serum phosphate, and low bone mass. (1,(4)(5)(6)(7)(8)(9)(10) Serum parathyroid hormone (PTH) is normal in the vast majority of patients.…”

Myositis Ossificans Progressiva (Munchmeyer's Disease): Brief review with report of two cases treated with corticosteroids and observed for 16 years

“…Lutwak (1964) studied a case on his metabolic unit for a year, giving triiodothyronine, thiouracil, and EDTA, to no avail. Liberman et al (1967) found that EDTA given in an acute exacerbation caused a disappearance of local inflammatory signs, with increased urinary excretion of calcium, phosphorus, and manganese. Bassett et al (1969) treated three cases with disodium ethane-l-hydroxy 1, 1-diphosphate (EHDP), 10 mg/kg by mouth, and reported that in two cases newly formed soft tissue swellings regressed in a few days, and that exacerbation occurred when the treatment was discontinued.…”