Myostatin and adipokines: The role of the metabolically unhealthy obese phenotype in muscle function and aerobic capacity in young adults

Carvalho, Lívia Pinheiro; Basso-Vanelli, Renata Pedrolongo; Thommazo-Luporini, Luciana Di; Mendes, Renata Gonçalves; Oliveira-Júnior, Manoel Carneiro; Vieira, Rodolfo de Paula; Bonjorno-Junior, José Carlos; Oliveira, Cláudio Ricardo de; Luporini, Rafael Luís; Borghi‐Silva, Audrey

doi:10.1016/j.cyto.2017.12.008

Cited by 26 publications

(20 citation statements)

References 52 publications

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“…Most studies indicate that a higher circulating myostatin concentration can be found in patients with higher muscle mass [ 79 , 80 , 81 , 82 , 83 , 84 , 85 ], but a few research studies resulted in finding such an association only in men [ 86 , 87 ], and some did not show any correlation with muscle mass parameters at all [ 88 , 89 , 90 , 91 ]. A study on healthy, obese and metabolically unhealthy participants found a contradictory, significantly negative correlation between muscle mass and serum myostatin, suggesting a major influence of metabolic syndrome on circulating myostatin level [ 92 ]. Similarly, contradictory findings have been made regarding the relationship between serum myostatin and muscle function.…”

Section: Myostatin and Muscle Wastingmentioning

confidence: 99%

“…Similarly, contradictory findings have been made regarding the relationship between serum myostatin and muscle function. Some studies found increased circulating myostatin concentrations in patients with better muscle function or physical performance [ 80 , 81 , 83 , 84 , 87 ], and several indicated such a relationship to be more apparent in the male population [ 85 , 93 ], while others did not show any clear correlation between those parameters [ 82 , 88 , 89 , 92 , 94 ].…”

Section: Myostatin and Muscle Wastingmentioning

confidence: 99%

“…However, Tsioga et al, found no correlation between body mass and serum myostatin among obese patients [ 149 ]. This result could be partly explained by a subsequent study by Carvalho et al, which demonstrated that among obese patients, only metabolically unhealthy ones (defined as presenting ≥3 criteria for metabolic syndrome combined with insulin resistance) are characterized by higher circulating myostatin levels, in comparison to healthy lean individuals [ 92 ]. The same study found that myostatin levels are correlated with the number of metabolic syndrome criteria met, insulin levels and insulin sensitivity.…”

Section: Factors Affecting Myostatin Concentrationmentioning

confidence: 99%

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Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps

2020

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Sarcopenia is a geriatric syndrome with a significant impact on older patients’ quality of life, morbidity and mortality. Despite the new available criteria, its early diagnosis remains difficult, highlighting the necessity of looking for a valid muscle wasting biomarker. Myostatin, a muscle mass negative regulator, is one of the potential candidates. The aim of this work is to point out various factors affecting the potential of myostatin as a biomarker of muscle wasting. Based on the literature review, we can say that recent studies produced conflicting results and revealed a number of potential confounding factors influencing their use in sarcopenia diagnosing. These factors include physiological variables (such as age, sex and physical activity) as well as a variety of disorders (including heart failure, metabolic syndrome, kidney failure and inflammatory diseases) and differences in laboratory measurement methodology. Our conclusion is that although myostatin alone might not prove to be a feasible biomarker, it could become an important part of a recently proposed panel of muscle wasting biomarkers. However, a thorough understanding of the interrelationship of these markers, as well as establishing a valid measurement methodology for myostatin and revising current research data in the light of new criteria of sarcopenia, is needed.

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Section: Myostatin and Muscle Wastingmentioning

confidence: 99%

Section: Myostatin and Muscle Wastingmentioning

confidence: 99%

Section: Factors Affecting Myostatin Concentrationmentioning

confidence: 99%

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Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps

2020

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“…It has been proven that myostatin can interfere with protein synthesis as well as protein breakdown in proliferating and adult myofibers [8, 9]. Myostatin, along with other TGF- β -related factors, also plays key roles in the growth, development, and regulation of diverse cellular functions in other types of cells [10, 11].…”

Section: Introductionmentioning

confidence: 99%

Label-Free LC-MS/MS Proteomics Analyses Reveal Proteomic Changes AccompanyingMSTNKO in C2C12 Cells

Wang

Huang

Wang

2019

BioMed Research International

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Analysis of the proteome of myostatin (MSTN) knockout (KO) mouse C2C12 cells has proven valuable to studies investigating the molecular mechanisms by which MSTN regulates skeletal muscle development. To identify new protein/pathway alterations and candidate biomarkers for skeletal muscle development, we compared proteomic profiles of MSTN KO C2C12 cells (KO) with corresponding wild-type cells (NC) using a label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique. A total of 2637 proteins were identified and quantified in KO cells. Among these proteins, 77 proteins were significantly differentially expressed, 38 upregulated, and 39 downregulated, in MSTN KO C2C12 cells. These significantly altered proteins are involved in metabolic processes, developmental processes, immune system processes, and the regulation of other biological processes. Enrichment analysis was utilized to link these alterations to biological pathways, which are predominantly related to oxidative phosphorylation, protein digestion and absorption, mitochondrion localisation, antigen processing and presentation, the MAPK signaling pathway, the PPAR signaling pathway, the PI3K-Akt signaling pathway, and the JAK-STAT signaling pathway. Upregulation of several proteins, including epoxide hydrolase, tropomyosin 1, Cyb5a, HTRA1, Cox6a1, CD109, Synap29, and Ugt1a6, likely enhanced skeletal muscle development, the immune system, and energy metabolism. Collectively, our results present a comprehensive proteomics analysis of MSTN KO C2C12 myoblast cells; we hypothesize that MSTN KO could activate p38MAPK signaling pathway by CDC42, and we further deciphered the function of MSTN in the regulation of skeletal muscle development, immune processes, and mitochondrial energy metabolism.

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“…Surprisingly, no investigation in the current literature explicitly investigated the link between the MHO or MUO phenotypes and myokines. Only one study by Carvalho et al [84] examining 61 adults aged 20-45 years was able to show a correlation between myostatin levels and TNF-α, and between leptin/adiponectin ratio and VO 2 peak [84]. In a different investigation, 10 metabolically healthy obese women had higher cardiorespiratory fitness and lower TNF-α levels than 10 age-and weight-matched women with metabolic syndrome [85].…”

Section: Tnf-αmentioning

confidence: 95%

Metabolic Health—The Role of Adipo-Myokines

Gräf

Ferrari

2019

IJMS

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Obesity is now a worldwide epidemic. In recent years, different phenotypes of obesity, ranging from metabolically healthy normal weight to metabolically unhealthy obese, were described. Although there is no standardized definition for these phenotypes or for metabolic health, the influence of lifestyle and early-life factors is undisputed. In this context, the ratio of muscle-to-fat tissue seems to play a crucial role. Both adipose tissue and skeletal muscle are highly heterogeneous endocrine organs secreting several hormones, with myokines and adipokines being involved in local autocrine/paracrine interactions and crosstalk with other tissues. Some of these endocrine factors are secreted by both tissues and are, therefore, termed adipo-myokines. High (cardiorespiratory) fitness as a surrogate parameter for an active lifestyle is epidemiologically linked to “better” metabolic health, even in the obese; this may be partly due to the role of adipo-myokines and the crosstalk between adipose and muscle tissue. Therefore, it is essential to consider (cardiovascular) fitness in the definition of metabolically healthy obese/metabolic health and to perform longitudinal studies in this regard. A better understanding of both the (early-life) lifestyle factors and the underlying mechanisms that mediate different phenotypes is necessary for the tailored prevention and personalized treatment of obesity.

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Myostatin and adipokines: The role of the metabolically unhealthy obese phenotype in muscle function and aerobic capacity in young adults

Cited by 26 publications

References 52 publications

Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps

Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps

Label-Free LC-MS/MS Proteomics Analyses Reveal Proteomic Changes AccompanyingMSTNKO in C2C12 Cells

Metabolic Health—The Role of Adipo-Myokines

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