Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis

Di Cola, Simone; D’Amico, Gennaro; Caraceni, Paolo; Schepis, Filippo; Loredana, Simone; Lampertico, Pietro; Toniutto, Pierluigi; Martini, Silvia; Maimone, Sergio; Colecchia, Antonio; Svegliati Barone, Gianluca; Alessandria, Carlo; Aghemo, Alessio; Crocè, Saveria Lory; Adinolfi, Luigi Elio; Rendina, Maria; Lapenna, Lucia; Pompili, Enrico; Zaccherini, Giacomo; Saltini, Dario; Iavarone, Massimo; Tosetti, Giulia; Martelletti, Carolina; Nassisi, Veronica; Ferrarese, Alberto; Giovo, Ilaria; Masetti, Chiara; Pugliese, Nicola; Campigotto, Michele; Nevola, Riccardo; Merli, Manuela; Iannone, Giulia; Serri, Paola; Bertino, Gaetano; Balsano, Clara; Iapadre, Nerio; Maida, Marcello; Sacerdoti, David; Natola, Leonardo Antonio; Ciacci, Carolina; Santonicola, Antonella; Cozzolongo, Raffaele; Surace, Lorenzo Antonio; Fracanzani, Anna Ludovica; Cespiati, Annalisa; Federico, Alessandro; Romeo, Mario; Grieco, Antonio; Marrone, Giuseppe; Vizioli, Luca

doi:10.1016/j.jhep.2024.05.020

Journal of Hepatology

2024

DOI: 10.1016/j.jhep.2024.05.020

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Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis

Simone Di Cola,

Gennaro D’Amico,

Paolo Caraceni

et al.

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Cited by 11 publications

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Strength in quality: Myosteatosis as a predictor of survival in advanced hepatocellular carcinoma

Campani,

Berzigotti

2024

UEG Journal

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Hepatocellular carcinoma (HCC) prognosis remains challenging due to late-stage diagnoses, compounded by the absence of biomarkers to predict treatment response. Therapeutic decisions are guided by the Barcelona Clinic Liver Cancer (BCLC) classification, which stratifies patients based on tumor burden, liver function, and performance status, aiming to optimize treatment outcomes by considering the performance of the individual patient. 1 There is a need for objective and measurable data that is able to assess it. Analysis of body composition on CT or MRI may offer us with potential prognostic imaging biomarkers. Sarcopenia, defined as a reduced skeletal muscle mass and function, has been recognized as such a biomarker. Sarcopenia contributes to a worse prognosis of HCC. While reduced muscle mass is relevant, we should also consider qualitative changes in muscle composition. Myosteatosis is characterised by excessive This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Strength in quality: Myosteatosis as a predictor of survival in advanced hepatocellular carcinoma

Campani,

Berzigotti

2024

UEG Journal

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Skeletal muscle density as a new predictor of abdominal infection in abdominal trauma patients

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Zheng,

Xiong

et al. 2024

Clinical Nutrition

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Scoparone alleviates nonalcoholic fatty liver disease by modulating the PPARα signaling pathway

Huang,

Yang,

Liu

et al. 2024

European Journal of Pharmacology

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Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis

Cited by 11 publications

References 37 publications

Strength in quality: Myosteatosis as a predictor of survival in advanced hepatocellular carcinoma

Strength in quality: Myosteatosis as a predictor of survival in advanced hepatocellular carcinoma

Skeletal muscle density as a new predictor of abdominal infection in abdominal trauma patients

Scoparone alleviates nonalcoholic fatty liver disease by modulating the PPARα signaling pathway

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