Myotonic dystrophy with electrocardiographic abnormalities Report of a case

Miller, Perry B.

doi:10.1016/0002-8703(62)90017-0

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…Evidence of cardiac disease in patients with myotonic dystrophy is usually found in the electrocardiogram, the most common alterations being P and ST and T wave abnormalities, first degree atrioventricular block, left axis deviation, atrial flutter and fibrillation, bundle-branch block, and premature atrial and ventricular contractions (DeWind and Jones, 1950;Fisch, 1951;Cannon, 1962;Miller, 1962;Payne and Greenfield, 1963;Fearrington et al, 1964;Church, 1967). There is still little information on the functional abnormality of cardiac muscle in these patients, because in the majority there is insufficient indication for invasive investigations such as cardiac catheterisation and angiocardiography.…”

mentioning

confidence: 99%

Noninvasive assessment of left ventricular function in myotonic muscular dystrophy.

Venco¹,

Saviotti²,

Besana³

et al. 1978

Heart

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Myotonic muscular dystrophy is a diffuse systemic disorder, which is inherited as an autosomal dominant trait, with appearance in both sexes, generally late onset of symptoms, and slowly progressive evolution. The clinical picture may include involvement of skeletal and cardiac muscle, cataracts, premature frontal baldness, bone changes, testicular atrophy, other mild endocrine abnormalities, and mental deterioration.Evidence of cardiac disease in patients with myotonic dystrophy is usually found in the electrocardiogram, the most common alterations being P and ST and T wave abnormalities, first degree atrioventricular block, left axis deviation, atrial flutter and fibrillation, bundle-branch block, and premature atrial and ventricular contractions

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mentioning

confidence: 99%

Noninvasive assessment of left ventricular function in myotonic muscular dystrophy.

Venco¹,

Saviotti²,

Besana³

et al. 1978

Heart

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“…Other reported findings included atrial flutter (Afl) and fibrillation (Afib) as well as bundle branch blocks [ 14 ]. Throughout the 1950s and 1960s there were many reports with a variety of cardiac conduction abnormalities in DM1 [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Conduction defects were often noted to have preceded overt skeletal muscle effects.…”

Section: History Of Cardiac Disease In Dm1mentioning

confidence: 99%

Cardiac Pathology in Myotonic Dystrophy Type 1

Mahadevan

Yadava

Mandal

2021

IJMS

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Myotonic dystrophy type 1 (DM1), the most common muscular dystrophy affecting adults and children, is a multi-systemic disorder affecting skeletal, cardiac, and smooth muscles as well as neurologic, endocrine and other systems. This review is on the cardiac pathology associated with DM1. The heart is one of the primary organs affected in DM1. Cardiac conduction defects are seen in up to 75% of adult DM1 cases and sudden death due to cardiac arrhythmias is one of the most common causes of death in DM1. Unfortunately, the pathogenesis of cardiac manifestations in DM1 is ill defined. In this review, we provide an overview of the history of cardiac studies in DM1, clinical manifestations, and pathology of the heart in DM1. This is followed by a discussion of emerging data about the utility of cardiac magnetic resonance imaging (CMR) as a biomarker for cardiac disease in DM1, and ends with a discussion on models of cardiac RNA toxicity in DM1 and recent clinical guidelines for cardiologic management of individuals with DM1.

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The Heart in Myotonia Atrophica

Church¹

1967

Arch Intern Med

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Myotonic dystrophy with electrocardiographic abnormalities Report of a case

Cited by 10 publications

References 7 publications

Noninvasive assessment of left ventricular function in myotonic muscular dystrophy.

Noninvasive assessment of left ventricular function in myotonic muscular dystrophy.

Cardiac Pathology in Myotonic Dystrophy Type 1

The Heart in Myotonia Atrophica

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