Myoxinol ointment for the treatment of acute fissure

Abstract

Myoxinol is a complex of oligopeptides obtained from the seeds of Hibiscus esculentus used in cosmetic as natural alternative to botulin toxin. The aim of the study was to evaluate the safety and effectiveness of local myoxinol for the treatment of acute anal fissure. All the consecutive patients with acute fissure treated from January to June 2014 underwent 30 days of topical treatment (twice/day) with a mioxinol based ointment. Pain, symptomatic relief, fissure healing and re-epithelization, 1-year recurrence rate, subjective satisfaction and need for further treatments were evaluated. During the study period 157 patients were eligible for data analysis (91 males: 58%; mean age 38 years: range 17-83). Median anal pain score was 7.1 pre-treatment and 1.7 and 0.9 after 30 days and 12 months from treatment, respectively (p: 0.0001). After the treatment period complete healing was achieved in 103 patients (65.5%), relevant improvement in 31 (20%) and no improvement in 21 patients (13.5%). Overall efficacy rate was 85.5%. A significant difference was reported considering patients with pre-treatment VAS between 1-5 and 6-10 (p: 0.004). Twenty-nine patients (18.5%) required further treatments. Hydrolyzed Hibiscus esculentus extract was proven to be an effective and well-tolerated topical treatment for acute fissure, with a high healing rate, a significant reduction of pain and a low 1-year recurrence rate.

The importance of topical metronidazole in the treatment of acute anal fissure: a double-blind study controlled for prospective randomization

“…Alvandipour et al [ 20 ] reported that the mean VAS score level of the patients, who had received topical diltiazem treatment in the treatment of chronic anal fissure was 3.2± 0.25 at the beginning of the treatment, and the VAS score level was reduced to 2.32± 0.32 at the end of 1 month of treatment. On the other hand, in a study by Martellucci et al [ 21 ], evaluating patients with acute anal fissure, the median VAS score was 7.1 (range, 2–10) at the beginning of the treatment, and 1.7 at the end of 1 month of treatment. In a retrospective study of patients with acute anal fissure, Emile et al [ 22 ] reported that the mean VAS score level was 8.8 ± 0.96 before treatment, and the mean VAS score level was 0.47± 0.8 after 6 weeks of treatment.…”

Scanner-Assisted CO2 Laser Fissurectomy: A Pilot Study

“…Then, we focused on other secondary endpoints: the proportion of patients healed at 1 week and then at 1-month follow-up and graded according to a previous published degree of reepithelisation scale (0—deep fissure still present, 1—superficial fissure, 2—partial reepithelisation, 3—complete healing and reepithelisation); by the end of fissurectomy, all patients were found to be at the lowest grade ( 17 ).…”

Fissure-In-ANO

“…Parasympathomimetic medications such as Bethanechol and Indoramin (alpha blocker), beta agonists like Salbutamol, natural products like Myoxinol ointment [41], egg yolks [42], and injection of sclerosing agents [43] have been tried with varying results.…”