Myricetin: A review of the most recent research

Song, Xiaominting; Tan, Lu; Wang, Miao; Ren, Chaoxiang; Guo, Chuanjie; Yang, Bo; Ren, Yali; Cao, Zhixing; Li, Yuzhi; Pei, Jin

doi:10.1016/j.biopha.2020.111017

Cited by 212 publications

(121 citation statements)

References 206 publications

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“…Its formula is shown in Fig. 2 c. Studies have shown that myricetin exerts a wide range of pharmacological effects, including anticancer, anti-inflammatory, antioxidant and antiviral effects [ 55 , 56 ]. Accumulating experimental data have shown that myricetin plays an essential therapeutic role in the attenuation of hyperglycaemia and hyperlipidaemia.…”

Section: Flavonoids For the Treatment Of Diabetic Nephropathymentioning

confidence: 99%

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

Xiaolin

et al. 2021

Chin Med

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With the advances in biomedical technologies, natural products have attracted substantial public attention in the area of drug discovery. Flavonoids are a class of active natural products with a wide range of pharmacological effects that are used for the treatment of several diseases, in particular chronic metabolic diseases. Diabetic nephropathy is a complication of diabetes with a particularly complicated pathological mechanism that affects at least 30% of diabetic patients and represents a great burden on public health. A large number of studies have shown that flavonoids can alleviate diabetic nephropathy. This review systematically summarizes the use of common flavonoids for the treatment of diabetic nephropathy. We found that flavonoids play a therapeutic role in diabetic nephropathy mainly by regulating oxidative stress and inflammation. Nrf-2/GSH, ROS production, HO-1, TGF-β1 and AGEs/RAGE are involved in the process of oxidative stress regulation. Quercetin, apigenin, baicalin, luteolin, hesperidin, genistein, proanthocyanidin and eriodictyol were found to be capable of alleviating oxidative stress related to the aforementioned factors. Regarding inflammatory responses, IL-1, IL-6β, TNF-α, SIRT1, NF-κB, and TGF-β1/smad are thought to be essential. Quercetin, kaempferol, myricetin, rutin, genistein, proanthocyanidin and eriodictyol were confirmed to influence the above targets. As a result, flavonoids promote podocyte autophagy and inhibit the overactivity of RAAS by suppressing the upstream oxidative stress and inflammatory pathways, ultimately alleviating DN. The above results indicate that flavonoids are promising drugs for the treatment of diabetic nephropathy. However, due to deficiencies in the effect of flavonoids on metabolic processes and their lack of structural stability in the body, further research is required to address these issues.

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Section: Flavonoids For the Treatment Of Diabetic Nephropathymentioning

confidence: 99%

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

Xiaolin

et al. 2021

Chin Med

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“…The Predicated Pa-Pi-Pmax and the probable bioactivity of the compound are given in Table 8. Studies on Myricetin has been surmounting in recent times due to its overwhelmed biological role in human healthcare 6,24 . Myricetin plays an important role as antioxidant 16 , anticancer 25,26 , anti-inflammatory 27,28 , anti-amyloidogenic 29 , antibacterial 30 , antiviral 31 , and antidiabetic 32 agent.…”

Section: 53mentioning

confidence: 99%

“…Dang et al 46 demonstrated that owing to poor absorption, Myricetin showed low oral bioavailability. Studies have established that Myricetin has a therapeutic effect on different types of tumors, inflammatory diseases, atherosclerosis, thrombosis, cerebral ischemia, diabetes, Alzheimer's disease and pathogenic microbial infections 6 . Furthermore, Myricetin significantly enhances the immunomodulatory functions, suppresses cytokine storms, and improves cardiac-dysfunction.…”

Section: 53mentioning

confidence: 99%

“…Myricetin is a polyhydroxyflavonol compound composed of light yellow crystals, soluble in methanol, acetonitrile, ethanol and other polar solvents. Its chemical formula is C15H10O8 and the relative molecular mass is 318.24 6 .…”

Section: Introductionmentioning

confidence: 99%

“…S. cumini has been reported to contain Ellagic acid, Triterpenoids, acetyl Oleanolic acid, Quercetin, Isoquercitin, Myricetin and Kaempferol 20 . S. cumini possesses enormous phytochemicals, of all, Myricetin has been widely reported for hypoglycemic, antimicrobial, hypolipidemic, anti-allergic, antiinflammatory, cardio-protective, hepatoprotective and antineoplastic properties 3,6,20,22 .…”

Section: Introductionmentioning

confidence: 99%

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Physicochemical, ADMET and Druggable properties of Myricetin: A Key Flavonoid in Syzygium cumini that regulates metabolic inflammations

Soorya¹,

Balamurugan²,

Ramya³

et al. 2021

J. Drug Delivery Ther.

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Syzygium cumini (Myrtaceae) is a potential medicinal plant traditionally used in indigenous systems of medicines practiced in India and elsewhere due to its functional properties against metabolic inflammations viz., anti-hyperglycemic, anti-inflammatory, cardio-protective, and antioxidant activities. Targeting metabolic inflammation has emerged as a standalone strategy to attenuate metabolic disease. Myricetin (3,5,7,3′,4′,5′-hexahydroxyflavone) is one of the flavonoids from stem bark, leaf, flowers, fruits, pulp and seeds of S. cumini. Therefore, attention has been paid to explore bioactive potentials of this compound in S. cumini owing to its exemplary therapeutic prospective and health-promoting effects. Antioxidant effect of Myricetin from S. cumini has been though experimentally demonstrated, therapeutic potential of Myricetin has not been fully explored. In the present study, physicochemical, ADMET and druggability properties of Myricetin - a key flavonoid compound in S. cumini have been evaluated. Data implicates that this molecule of GRAS standard can be a novel jumble-sale lead in drug discovery. Keywords: Plant Based Natural Products (PBNPs); Drug Discovery; Pharmacological Activity; ADMET Properties; Flavonoid; Myricetin; Syzygium cumini

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