Myricetin ameliorates scopolamine-induced memory impairment in mice via inhibiting acetylcholinesterase and down-regulating brain iron

Wang, Beiyun; Zhong, Yuan; Gao, Chengjie; Li, Jingbo

doi:10.1016/j.bbrc.2017.06.045

Cited by 59 publications

(38 citation statements)

References 32 publications

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“…Caffeic acid phenetyl ester, a derivative of chlorogenic acid, has also been shown to be effective in stimulating endothelial function and vascular hypertrophy in hypertensive rats [ 54 ]. Myricetin-3- O -β-rhamnoside is effective in improving memory impairment in mice through inhibiting acetylcholinesterase [ 55 ]. It is also an alternative multi-target antivirulence candidate for controlling Staphylococcus aureus [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Wound Healing Potential of Chlorogenic Acid and Myricetin-3-O-β-Rhamnoside Isolated from Parrotia persica

et al. 2017

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Wound healing is a complex physiological process that is controlled by a well-orchestrated cascade of interdependent biochemical and cellular events, which has spurred the development of therapeutics that simultaneously target these active cellular constituents. We assessed the potential of Parrotia persica (Hamamelidaceae) in wound repair by analyzing the regenerative effects of its two main phenolic compounds, myricetin-3-O-β-rhamnoside and chlorogenic acid. To accomplish this, we performed phytochemical profiling and characterized the chemical structure of pure compounds isolated from P. persica, followed by an analysis of the biological effects of myricetin-3-O-β-rhamnoside and chlorogenic acid on three cell types, including keratinocytes, fibroblasts, and endothelial cells. Myricetin-3-O-β-rhamnoside and chlorogenic acid exhibited complementary pro-healing properties. The percentage of keratinocyte wound closure as measured by a scratch assay was four fold faster in the presence of 10 μg/mL chlorogenic acid, as compared to the negative control. On the other hand, myricetin-3-O-β-rhamnoside at 10 μg/mL was more effective in promoting fibroblast migration, demonstrating a two-fold higher rate of closure compared to the negative control group. Both compounds enhanced the capillary-like tube formation of endothelial cells in an in vitro angiogenesis assay. Our results altogether delineate the potential to synergistically accelerate the fibroblastic and remodelling phases of wound repair by administering appropriate amounts of myricetin-3-O-β-rhamnoside and chlorogenic acid.

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Section: Discussionmentioning

confidence: 99%

Wound Healing Potential of Chlorogenic Acid and Myricetin-3-O-β-Rhamnoside Isolated from Parrotia persica

et al. 2017

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“…Myricetin, a plant flavonol abundant in fruits such as berries and grapes has been well known to act as effective therapeutic against diabetes mellitus [ 61 ]. A new study on mice revealed that myricetin ameliorated memory deficits thereby acting as an effective drug target for Alzheimer’s disease [ 62 ]. It was reported that myricetin induces apoptosis and enhanced cytotoxicity in ovarian cancer cell lines proving potential against ovarian cancer, the most lethal gynaecological cancer [ 63 ].…”

Section: Structure–activity Relationship (Sar) Studies In Fruit Bioacmentioning

confidence: 99%

Fruits as Prospective Reserves of bioactive Compounds: A Review

Karasawa

Mohan

2018

Nat. Prod. Bioprospect.

132

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Bioactive natural products have always played a significant role as novel therapeutical agents irrespective of their source of origin. They have a profound effect on human health by both direct and indirect means and also possess immense medicinal properties. Fruit species are largely appreciated and highly consumed throughout the world. Epidemiologic information supports the association between high intake of fruits and low risk of chronic diseases. There are several biological reasons why the consumption of fruits might reduce or prevent chronic diseases. Fruits are rich sources of nutrients and energy, have vitamins, minerals, fiber and numerous other classes of biologically active compounds. Moreover, parts of the fruit crops like fruit peels, leaves and barks also possess medicinal properties and have been included in this review. The most important activities discussed in this review include antidiabetic, anticancer, antihypertensive, neuroprotective, anti-inflammatory, antioxidant, antimicrobial, antiviral, stimulation of the immune system, cell detoxification, cholesterol synthesis, anticonvulsant and their ability to lower blood pressure. Several phytochemicals involved in this context are described with special emphasis on their structural properties and their relativity with human diseases.

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“…Furthermore, Myricetin treatment reduced oxidative damage and increased antioxidant enzymes activity in mice. Interestingly, the effect of Myricetin was largely abolished by high iron diet [45].…”

Section: Anti-alzheimer Activitymentioning

confidence: 99%

Current Pharmacological Trends on Myricetin

et al. 2020

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Myricetin is a member of the group of ﬂavonoids called ﬂavonols. Myricetin is obtained from various fruit, vegetables, tea, berries and red wine. Myricetin is characterized by the pysrogallol B-ring, and the more hydroxylated structure is known to be capable for its increased biological properties compared with other ﬂavonols. Myricetin is produced by the Myricaceae, Anacardiaceae, Polygonaceae, Pinaceae and Primulacea families. It is soluble in organic solvent such as ethanol, DMSO (dimethyl sulfoxide), and dimethyl formamide (DMF). It is sparingly soluble in aqueous buffers. Myricetin shows its various pharmacological activities including antioxidant, anti-amyloidogenic, antibacterial, antiviral, antidiabetic, anticancer, anti-inﬂammatory, anti-epileptic and anti-ulcer. This review article focuses on pharmacological effects of Myricetin on different diseases such as osteoporotic disorder, anti-inflammatory disorder, alzheimer’s disease, anti-epileptic, cancer, cardiac disorder, diabetic metabolic disorder, hepatoprotective disorder and gastro protective disorder.

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Myricetin ameliorates scopolamine-induced memory impairment in mice via inhibiting acetylcholinesterase and down-regulating brain iron

Cited by 59 publications

References 32 publications

Wound Healing Potential of Chlorogenic Acid and Myricetin-3-O-β-Rhamnoside Isolated from Parrotia persica

Wound Healing Potential of Chlorogenic Acid and Myricetin-3-O-β-Rhamnoside Isolated from Parrotia persica

Fruits as Prospective Reserves of bioactive Compounds: A Review

Current Pharmacological Trends on Myricetin

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