Myricetin blocks lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts

Gutiérrez-Venegas, Gloria; Luna, Oscar Alonso; Arreguín-Cano, Juan Antonio; Hernández-Bermúdez, Cristina

doi:10.2478/s11658-014-0186-4

Cited by 14 publications

(10 citation statements)

References 52 publications

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“…Early studies in various literatures suggested it has the aptitude in reducing COX-2 expression in cancer [ 62 – 66 ] or noncancerous cell [ 67 , 68 ]. Myricetin is a widely distributed flavonol that is found in many plants, including tea, berries, fruits, vegetables, and medicinal herbs attenuated the COX-2 expression UVB-induced skin cancer [ 69 – 71 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer

et al. 2015

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Cyclooxygenase-2 (COX-2) catalyzed synthesis of prostaglandin E2 and it associates with tumor growth, infiltration, and metastasis in preclinical experiments. Known inhibitors against COX-2 exhibit toxicity. Therefore, it is of interest to screen natural compounds like flavanoids against COX-2. Molecular docking using 12 known flavanoids against COX-2 by FlexX and of ArgusLab were performed. All compounds showed a favourable binding energy of >-10 KJ/mol in FlexX and > -8 kcal/mol in ArgusLab. However, this data requires in vitro and in vivo verification for further consideration.

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Section: Resultsmentioning

confidence: 99%

Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer

et al. 2015

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“…Collectively, panduratin A suppresses gingival inflammation and osteoclastogenesis by inhibiting at least one pathway, MAPK, in LPS-stimulated HGF-1 and RANKL-treated RAW 264.7 cells. Previous studies reported several natural MAPK pathway inhibitors on periodontal inflammation from medicinal plants [25,26]. Although myricetin, luteolin, morin, and fisetin have been shown to reduce MAPK protein expression in periodontal cell lines, these natural compounds were used at a higher concentration than that of panduratin A [25,26].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Kim¹,

Kim²,

Kim³

et al. 2018

Journal of Microbiology and Biotechnology

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Periodontitis is an inflammatory disease caused by microbial lipopolysaccharide (LPS), destroying gingival tissues and alveolar bone in the periodontium. In the present study, we evaluated the anti-inflammatory and anti-osteoclastic effects of panduratin A, a chalcone compound isolated from , in human gingival fibroblast-1 (HGF-1) and RAW 264.7 cells. Treatment of panduratin A to LPS-stimulated HGF-1 significantly reduced the expression of interleukin-1β and nuclear factor-kappa B (NF-κB), subsequently leading to the inhibition of matrix metalloproteinase-2 (MMP-2) and MMP-8 compared with that in the LPS control (** < 0.01). These anti-inflammatory responses were mediated by suppressing the mitogen-activated protein kinase (MAPK) signaling and activator protein-1 complex formation pathways. Moreover, receptor activator of NF-κB ligand (RANKL)-stimulated RAW 264.7 cells treated with panduratin A showed significant inhibition of osteoclastic transcription factors such as nuclear factor of activated T-cells c1 and c-Fos as well as osteoclastic enzymes such as tartrate-resistant acid phosphatase and cathepsin K compared with those in the RANKL control (** < 0.01). Similar to HGF-1, panduratin A suppressed osteoclastogenesis by controlling MAPK signaling pathways. Taken together, these results suggest that panduratin A could be a potential candidate for development as a natural anti-periodontitis agent.

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“…Activation of ERK-1/2, AKT and p38, and lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts was inhibited by the compound. It also blocked IκB degradation and PGE2 synthesis and expression [ 127 , 128 ]. Myricetin did not have any effect on cell viability, but decreased the mRNA expression and enzyme activity of MMP-1, -2 and -8 in human growth factor (HGF).…”

Section: Pharmacological Applicationsmentioning

confidence: 99%

Myricetin: A Dietary Molecule with Diverse Biological Activities

et al. 2016

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Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. It displays several activities that are related to the central nervous system and numerous studies have suggested that the compound may be beneficial to protect against diseases such as Parkinson’s and Alzheimer’s. The use of myricetin as a preserving agent to extend the shelf life of foods containing oils and fats is attributed to the compound’s ability to protect lipids against oxidation. A detailed search of existing literature revealed that there is currently no comprehensive review available on this important molecule. Hence, the present work includes the history, synthesis, pharmaceutical applications and toxicity studies of myricetin. This report also highlights structure-activity relationships and mechanisms of action for various biological activities.

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Myricetin blocks lipoteichoic acid-induced COX-2 expression in human gingival fibroblasts

Cited by 14 publications

References 52 publications

Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer

Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer

Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro

Myricetin: A Dietary Molecule with Diverse Biological Activities

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