Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide

Knickle, Allison; Fernando, Wasundara; Greenshields, Anna L.; Rupasinghe, H.P. Vasantha

doi:10.1016/j.fct.2018.05.005

Cited by 70 publications

(37 citation statements)

References 47 publications

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“…The underlying mechanism involved both intrinsic and extrinsic apoptotic pathways confirmed by regulated expression of Bcl-2 and DR5 respectively [95]. Finally, the mechanism of myricetin induced apoptosis in TNBC was comprehended by the induction of ROS that resulted in DNA double strand breaks, and activation of mitochondrial apoptotic pathway [96].…”

Section: Phytochemicalsmentioning

confidence: 99%

Flavonoids in Cancer and Apoptosis

Abotaleb

Samuel

Varghese

et al. 2018

Cancers

568

394

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Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.

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Section: Phytochemicalsmentioning

confidence: 99%

Flavonoids in Cancer and Apoptosis

Abotaleb

Samuel

Varghese

et al. 2018

Cancers

568

394

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show abstract

“…DFX may selectively target the NF-κB pathway and induce highly specific apoptosis in myeloid leukemia, hepatoma and mantle cell lymphoma cells [170]. DFP has been reported to inhibit prostate cancer cell and TNBC cells proliferation and migration by decreasing oxygen consumption rate (OCR) and impairing mitochondrial function [171,172]. Megadose of DFO treatment disturbs intracellular iron homeostasis, induces apoptosis and represses growth in breast cancer cell lines [173].…”

Section: Iron Manipulating Strategies In Cancermentioning

confidence: 99%

Iron Metabolism in Cancer

Wang

Ding

et al. 2018

IJMS

221

159

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Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a considerable approach for cancer therapy. Several iron chelators and iron oxide nanoparticles (IONPs) has recently been developed for cancer intervention and presented considerable effects. This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in cancer diagnosis and therapy.

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“…Myricetin was shown to inhibit the proliferation of colon carcinoma cells [181], suppress extracellular signal-regulated (ERK) kinase phosphorylation and matrix metallopeptidase (MMP) enzyme activity and prevent invasion of colon cancer cells in a transwell migration assay [182]. Myricetin inhibited the growth of breast cancer cells to a greater extent than resveratrol and cisplatin and induced intracellular ROS and apoptosis in these cells [183]. Although myricetin demonstrates anti-cancer activity, the immunomodulatory effects of myricetin have mostly been studied in the context of dampening the T cell response as a possible autoimmune/autoreactive cell therapeutic.…”

Section: Myricetinmentioning

confidence: 99%

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

Moody

Wilson

Jaworowski

et al. 2020

Cancers

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Cancer-related deaths are approaching 10 million each year. Survival statistics for some cancers, such as ovarian cancer, have remained unchanged for decades, with women diagnosed at stage III or IV having over 80% chance of a lethal cancer recurrence after standard first-line treatment (reductive surgery and chemotherapy). New treatments and adjunct therapies are needed. In ovarian cancer, as in other cancers, the immune response, particularly cytotoxic (CD8+) T cells are correlated with a decreased risk of recurrence. As well as completely new antigen targets resulting from DNA mutations (neo-antigens), these T cells recognize cancer-associated overexpressed, re-expressed or modified self-proteins. However, there is concern that activation of self-reactive responses may also promote off-target pathology. This review considers the complex interplay between cancer-reactive and self-reactive immune cells and discusses the potential uses for various leading immunomodulatory compounds, derived from plant-based sources, as a cancer therapy option or to modulate potential autoimmune pathology. Along with reviewing well-studied compounds such as curcumin (from turmeric), epigallocatechin gallate (EGCG, from green tea) and resveratrol (from grapes and certain berries), it is proposed that compounds from novel sources, for example, native Australian plants, will provide a useful source for the fine modulation of cancer immunity in patients.

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Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide

Cited by 70 publications

References 47 publications

Flavonoids in Cancer and Apoptosis

Flavonoids in Cancer and Apoptosis

Iron Metabolism in Cancer

Natural Compounds with Potential to Modulate Cancer Therapies and Self-Reactive Immune Cells

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