Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities

Abstract

Excessive exposure to ultraviolet radiation (UV) can induce oxidative stress through the over-production of reactive oxygen species (ROS) on the skin. Myricetin (MYR), a natural flavonoid compound, significantly inhibited UV-induced keratinocyte damage; however, its bioavailability is limited by its poor water solubility and inefficient skin penetration ability, which subsequently influences its biological activity. The purpose of the study was to develop a myricetin nanofibers (MyNF) system of hydroxypropyl-β-cyclodextrin (HPBCD)/polyvinylpyrrolidone K120 (PVP)-loaded with MYR that would enhance the water solubility and skin penetration by changing the physicochemical characteristics of MYR, including reducing the particle size, increasing the specific surface area, and amorphous transformation. The results also revealed that the MyNF can reduce cytotoxicity in HaCaT keratinocytes when compared with MYR; additionally, MyNF had better antioxidant and photoprotective activity than raw MYR for the UVB-induced HaCaT keratinocytes damage model due to the MyNF increased water solubility and permeability. In conclusion, our results demonstrate that MyNF is a safe, photostable, and thermostable topical ingredient of antioxidant nanofibers to enhance the skin penetration of MYR and prevent UVB-induced skin damage.

Myricetin Amorphous Solid Dispersions—Antineurodegenerative Potential

“…The literature reports that improving apparent solubility can positively affect the biological properties of the compound [ 28 , 30 , 46 , 47 , 48 , 50 , 53 , 54 , 55 , 56 , 62 ]. Therefore, we examined how improving the solubility of MYR introduced into amorphous solid dispersions translated into changes in its biological properties, such as antioxidant potential and inhibition of enzymes influencing the development of neurodegenerative diseases.…”

“…Therefore, it is essential to use efficient techniques, such as delivery systems, to improve the solubility, absorption, and therapeutic potential of MYR. In the literature, attempts to improve the solubility of MYR using various techniques have been reported (e.g., cocrystals [ 23 , 24 ], micelles [ 25 , 26 , 27 ], inclusion complex [ 28 , 29 ], nanofibers [ 30 ], nanoliposomes [ 31 ], solid dispersion [ 32 , 33 ], amorphous solid dispersion [ 32 , 34 ], tooth-binding nanoparticles [ 35 ], nanoliposomes [ 36 ], lipid nanoparticles [ 37 ], pro-liposomes [ 38 ], and nanophytosomes [ 39 ]). For example, micelles obtained by Wang et al [ 25 ] significantly improved the solubility and effectiveness of MYR against glioblastoma cells.…”

Research progress in nucleus-targeted tumor therapy

“…89 The development of stimulus-sensitive nanocarriers has successfully fabricated various biostimulus-or endogenous stimulusresponsive delivery systems, which can control the gene delivery process in an intelligent manner and overcome the cascading systemic and intracellular barriers, thus fundamentally changing the landscape of nucleic acid drug delivery. 90,91 In order for nucleic acid drugs to be effective against cancer, therapeutic molecules must be delivered inside the target cell and to specific organelles to function well. 92,93 For effective and safe delivery to cancer cells, nucleic acids must usually be packaged into a vector.…”

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

“…Progress in host-guest interactions between CyDs and drugs or other guest molecules has been made and such interactions have shown great potentials in versatile fields, such as medical, sports, and pollution removal [17][18][19]. In aqueous solution, the solid crystalline structure can be broken and the as-formed individualized CyDs can form inclusion complexes with various substances or selfassociate with different aggregates (i.e.…”

“…MOFs derived from γ-CyD shows high specific surface area and has been used to prepare biocompatible and non-toxic MOFs. However, CyD MOFs are humid unstale and dissolution in water [17]. In order to overcome the decomposition or dissolution problems upon exposure to water and to further improve the drug loading efficiency, Jia et al modified poly(ethyleneglycol) dimethacrylate (PEGMA) via SI-ATRP onto the surface of γ-CyD-MOF (Figure 5Ⅰ) [128].…”