Myrsinoic acid B from Myrsine coriacea reverses depressive-like behavior and brain oxidative stress in streptozotocin-diabetic rats

Zimath, Priscila Laiz; Dalmagro, Ana Paula; Silva, Luísa Mota da; Malheiros, Ângela; Souza, Márcia María de

doi:10.1016/j.cbi.2021.109603

Cited by 7 publications

(8 citation statements)

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“…In this study, DM was induced using a combination of high fructose and STZ, resulting in severe hyperglycemia, and obvious body weight decrease. The inability of the β cells to secrete insulin in DM increases catabolism and gluconeogenesis, resulting in reduced body weight due to wasting of fat storage [ 7 , 30 ]. The increment in blood glucose level and subsequent weight reduction in the diabetic rats were restored upon treatment with MSE.…”

Section: Discussionmentioning

confidence: 99%

“…One of the most prevailing diabetes associated comorbidity is brain disorders and psychological problems including depression, anxiety, cognitive dysfunctions and Alzheimer’s disease. In fact, it has been reported that up to 30% of DM patients are suffering from depression [ 5 , 6 , 7 ]. In addition, there is a cordial relationship between hyperglycemia and depressive disorders, as patients exhibiting psychiatric and psychological disorders such as depression and anxiety are prone to increase risk for developing DM, while depression also increases the risk of metabolic disorders particularly DM [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, it has been reported that up to 30% of DM patients are suffering from depression [ 5 , 6 , 7 ]. In addition, there is a cordial relationship between hyperglycemia and depressive disorders, as patients exhibiting psychiatric and psychological disorders such as depression and anxiety are prone to increase risk for developing DM, while depression also increases the risk of metabolic disorders particularly DM [ 7 , 8 , 9 ]. Several factors, including decrease in neurotransmission, increased oxidative and inflammatory factors as well as decrease in antioxidant defense, have been shown to promote insulin resistance and facilitate DM-induced depression [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several factors, including decrease in neurotransmission, increased oxidative and inflammatory factors as well as decrease in antioxidant defense, have been shown to promote insulin resistance and facilitate DM-induced depression [ 10 , 11 ]. As such, mitigating hyperglycemia induced oxidative and inflammatory damage may obviously be a viable target in the treatment of DM-induced neuropsychiatric comorbidities [ 7 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

2022

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In this study, the attenuative effects of the hydro-alcoholic extract from Mitragyna speciosa (MSE) against diabetes-induced anxiety and depression-like behaviors were examined. In addition, UPLC/ESI/TOF-MS analysis was performed to identify the phytochemical nature of MSE. DM was induced using a combination of high fructose/streptozotocin, and the diabetic rats were treated with MSE (50 and 200 mg/kg) for 5 weeks. After treatment, the animals were subjected to a forced swim test, open field test and elevated plus-maze tests. Additionally, proinflammatory cytokines and oxidative stress parameters were evaluated in the brain tissues of the rats. UPLC/ESI/TOF-MS analysis revealed that MSE is abundantly rich in polyphenolic constituents, notably flavonoid and phenolic glycosides. Behavioral tests and biochemical analyses indicated that diabetic rats showed significantly increased anxiety and depressive-like behavioral deficits, brain oxidative stress and pro-inflammatory cytokines levels (IL-1β, IL-6 and TNF-α). Treatment with MSE (50 and 200 mg/kg) significantly attenuated increased blood glucose level, depressive and anxiety-like behaviors in diabetic rats. Additionally, the antioxidant enzymes activities were markedly increased in MSE-treated animals, while TNF-α, IL-1β and IL-6 cytokines were notably suppressed. Taken together, these results suggested that MSE has potentials as antidepressant and anxiolytic-like effects and improves the brain oxido-inflammatory status in diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

2022

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“…Numerous plant extracts showed antidepressant-like effects in behavioral tests conducted on mice, but more research is needed to further study the specific mechanisms of action. These include: Woodfordia fruticose leaf extract [323], myrsinoic acid B from Myrsine coriacea [324], parsley [325], Bacopa monnieri (Linn.) Wettst [326], Salvia officinalis, and Lippi triphylla [327].…”

Section: Plantsmentioning

confidence: 99%

Novel Pharmacological Approaches to the Treatment of Depression

Elias

Zhang

Manners

2022

Life

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Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-based antidepressants were the first drugs developed to treat major depressive disorder. More recently, ketamine and other analogues were introduced as fast-acting antidepressants. Unfortunately, currently available therapeutics are inadequate; lack of efficacy, adverse effects, and risks leave patients with limited treatment options. Efforts are now focused on understanding the etiology of depression and identifying novel targets for pharmacological treatment. In this review, we discuss promising novel pharmacological targets for the treatment of major depressive disorder. Targeting receptors including N-methyl-D-aspartate receptors, peroxisome proliferator-activated receptors, G-protein-coupled receptor 39, metabotropic glutamate receptors, galanin and opioid receptors has potential antidepressant effects. Compounds targeting biological processes: inflammation, the hypothalamic-pituitary-adrenal axis, the cholesterol biosynthesis pathway, and gut microbiota have also shown therapeutic potential. Additionally, natural products including plants, herbs, and fatty acids improved depressive symptoms and behaviors. In this review, a brief history of clinically available antidepressants will be provided, with a primary focus on novel pharmaceutical approaches with promising antidepressant effects in preclinical and clinical studies.

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The genus Myrsine: A review of phytochemistry, pharmacology, and toxicology

Thoa,

Son

2024

Fitoterapia

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Myrsinoic acid B from Myrsine coriacea reverses depressive-like behavior and brain oxidative stress in streptozotocin-diabetic rats

Cited by 7 publications

References 60 publications

LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

LC/ESI/TOF-MS Characterization, Anxiolytic and Antidepressant-like Effects of Mitragyna speciosa Korth Extract in Diabetic Rats

Novel Pharmacological Approaches to the Treatment of Depression

The genus Myrsine: A review of phytochemistry, pharmacology, and toxicology

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