Myth: Dementia is a Normal Part of Aging

Dobrowolski, Chrisanna

doi:10.15273/dmj.vol40no2.4539

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Several studies stress that the level of cognitive functioning is characterised by high heterogeneity across older adults (Aartsen et al, 2019). Most individuals experience subtle cognitive changes at older ages, such as variations in memory, executive function, attention, reasoning and spatial abilities (Rog and Fink, 2013;Blazer et al, 2015), which do not interfere negatively with their daily activities (Dobrowolski, 2014). However, some may suffer a decline greater than would be expected for their age (Petersen et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

The interrelationship between social connectedness and social engagement and its relation with cognition: a study using SHARE data

2021

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Understanding how psychosocial factors can promote better cognition in mid- and later life is important for making recommendations regarding policies and intervention programmes. This study focuses on two psychosocial aspects (social connectedness and social engagement) in order to assess their independent contribution to explaining cognition, but also how their interrelationship acts on cognition. We hypothesised that each of the factors is positively associated with cognition, but also that a combination of both factors contributes more to cognition than each of the factors independently. Our sample comprises 66,504 individuals who participated in the Survey of Health, Ageing and Retirement in Europe (SHARE). Multilevel linear regression analyses were performed. The results show that higher levels of social engagement and social connectedness are associated with improved cognition. When studying the interaction of social engagement and social connectedness and its association with cognitive function, the analysis shows that better cognitive scores are found in individuals having high levels of both social engagement and social connectedness. Moreover, when one of these aspects is lacking, the other plays a role in cognition protection. This study indicates the importance of social connectedness and social engagement for preserving/developing cognition, which greatly contributes to the quality of life of middle-aged and older adults.

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Section: Introductionmentioning

confidence: 99%

The interrelationship between social connectedness and social engagement and its relation with cognition: a study using SHARE data

2021

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“…Despite the fact that all healthy adults are subjected to these changes, it is important to highlight that age-related neurodegenerative disorders are not inclusive as a part of regular healthy aging conditions. These are mainly referred to Alzheimer's disease (AD) and other forms of dementia (Dobrowolski, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Potential Use of Sialic Acid From Edible Bird’s Nest to Attenuate Mitochondrial Dysfunction by In Vitro Study

et al. 2021

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Edible bird’s nest (EBN) is one of the expensive functional foods in herbal medicine. One of the major glyconutrients in EBN is sialic acid, which has a beneficial effect on neurological and intellectual capability in mammals. The aims of this research were to study the effects of sialic acid from EBN on cell viability and to determine its effect on mitochondria membrane potential (MtMP) in Caco-2, SK-N-MC, SH-SY5Y, and PC-12 cell lines. Fourteen samples of raw EBN were collected from four different states in Malaysia. The confluency of the epithelial monolayers measurement of the tight junction for all the cell lines was determined using transepithelial electrical resistance (TEER), and the sialic acid uptake study in cell lines was determined by using ultra-high performance liquid chromatography (UHPLC). The MTT assay was conducted for cell viability study. The MtMP in cell lines was determined using the Mito Probe JC-1 Assay by flow cytometer analysis. We have recorded a statistically significant difference between the uptake of sialic acid from EBN and the standard solution. A higher amount of sialic acid was absorbed by the cells from extract of EBN compared to the standard solution. The amounts of sialic acid uptake in Caco-2, SK-N-MC, SH-SY5Y, and PC-12 cell lines were (0.019 ± 0.001), (0.034 ± 0.006), (0.021 ± 0.002), and (0.025 ± 0.000) µmol/L, respectively. The MTT results indicated that the concentration of sialic acid increased the cell viability and showed no cytotoxicity effects on cell lines when they were exposed to the sialic acid extract and sialic acid standard at all the tested concentrations. The number of active mitochondria was found to be significantly higher in SH-SY5Y cell lines with a 195% increase when treated with sialic acid from EBN. Although many researchers around the globe use SH-SY5Y and SK-N-MC for Alzheimer’s disease (AD) study, based on our finding, SH-SY5Y was found to be the most suitable cell line for AD study by in vitro works where it has a known relationship with mitochondrial dysfunction.

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Myth: Dementia is a Normal Part of Aging

Cited by 2 publications

References 33 publications

The interrelationship between social connectedness and social engagement and its relation with cognition: a study using SHARE data

The interrelationship between social connectedness and social engagement and its relation with cognition: a study using SHARE data

The Potential Use of Sialic Acid From Edible Bird’s Nest to Attenuate Mitochondrial Dysfunction by In Vitro Study

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