Myxedema Madness: An Intriguing Case of Depression in Hypothyroidism

Abstract

Hypothyroidism is a clinical syndrome due to deficiency of thyroid hormone. Thyroid hormone is responsible for maintaining the brain hemostasis and helps in central nervous system global development. There have been studies on the association of psychiatric illness with thyroid deficiency and strikingly found to be presenting feature of hypothyroidism in many patients. Literature evidence also says that underlying hypothyroidism may lead to failure of psychiatric treatment. Hence, we report a case of hypertensive patient on medications started with antidepressants and antipsychotics after being diagnosed of depression but was found to be resistant to psychiatric medications and later successfully treated with levothyroxine for underlying hypothyroidism with myxedema.

The IN VITRO STUDY OF APOPTOSIS INDUCTION BY L-ASPARAGINASE OF ASPERGILLUS FUMIGATUS (ASPF-6) ON HUMAN LEUKEMIA CELL LINES

“…Early apoptotic events were detected using Annexin V/PI fluoro cytometric study [36,37]. The cells were cultured in a 6 well plate at a density of 3×10 5 cells/1mL and incubated in a CO 2 incubator overnight at 30°С for 24 h. The cells were then treated with experimental compound L-asparaginase and positive control doxorubicin, in 1 mL RPMI medium and again incubated for 24 h. The cells were transferred to 12 × 75 mm polystyrene tubes and centrifuged at 300× g at 25°С for 5 min, and the pellet was collected.…”

Medicinal Herbs and Phytochemicals Used in the Treatment of Depression: A Review

“…Since then there is no proper information regarding neuronal loops possessing the pathophysiology of the brain in depression (Table 1), the effort is made to note the significant hypothesis and some regions on depression [8]. The brain of a human was subjected to many types of research to have various alterations in the hippocampus, amygdala, striatum, prefrontal cortex, and cingulate cortex and many more, these irregularities in the brain were seen in a depressed patient during autopsy [9].…”