Myxofibrosarcoma Arising in the Maxillary Sinus: A Case Report with a Review of the Ultrastructural Findings and Differential Diagnoses

Norval, E. J. G.; Raubenheimer, Erich J.

doi:10.1007/s12663-011-0259-0

Cited by 14 publications

(6 citation statements)

References 48 publications

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“…6) MFS displays specific histopathologic features, including alternating areas of hypocellular and hypercellular fibrous tissue, pleomorphic nuclei, curvilinear thin-walled blood vessels in myxoid areas, and the presence of spindle and stellate cells. 1,10,11) The immunohistochemical staining revealed positivity for vimentin and CD-34, indicating a fibroblastic origin of the tumor. Smooth muscle actin was occasionally positive, whereas S-100 protein was negative.…”

Section: Discussionmentioning

confidence: 97%

A Case of Myxofibrosarcoma in the Maxillary Sinus

Oh,

Jeong,

Kim

et al. 2024

Korean J Otorhinolaryngol-Head Neck Surg

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Myxofibrosarcoma (MFS) is a rare subtype of soft tissue sarcoma, most commonly occurring in the lower extremities and rarely in the head and neck region. To our knowledge, there have been no reported cases of MFS originating from the maxillary sinus in Korea. Herein, we describe a case of a 61-year-old male who presented with left-sided hypoesthesia and a mass in the maxillary sinus, which was subsequently diagnosed as MFS originating from the maxillary sinus through endoscopic surgery with a prelacrimal approach. The patient was administered postoperative radiation therapy, and after two years of follow-up, there was no evidence of recurrence. This report presents a case of successful treatment of MFS in the maxillary sinus.

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Section: Discussionmentioning

confidence: 97%

A Case of Myxofibrosarcoma in the Maxillary Sinus

Oh,

Jeong,

Kim

et al. 2024

Korean J Otorhinolaryngol-Head Neck Surg

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“…Head and neck localization of Myxofibrosarcoma is extremely rare and up to our knowledge, this is the second case of thyroid myxofibrosarcoma in Africa after the case diagnosed from Côted'Ivoire14. Only 20 cases have been described in the head and neck [3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] so far, our case being the second one in the thyroid.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of these tumors arise in limbs but rarely in the trunk, head and neck, hands, and feet [1]. Few cases were reported in larynx [2], esophagus [3], sphenoid sinus [4,5], mandible [6], maxillary sinus [7], parotid [8,9], orbit [10,11] and infratemporal space [12]. To our knowledge, only one case was reported in the hypopharynx [13] and another case involved the thyroid [14].…”

Section: Introductionmentioning

confidence: 99%

Myxofibrosarcoma of the Thyroid: Second Case in Africa

Salama¹

2014

J Cytol Histol

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Myxofibrosarcoma is a common sarcoma in the extremities, but is rare in the head and neck region. Here, we report a case of 76 year old female patient in whom myxofibrosarcoma generated from the thyroid. The tumor was characterized by spindle cell proliferation with low to moderate cellular density in myxoid stroma. Immunohistochemically, the tumor cells showed positive reactivity for vimentin and actin, but negative staining for S-100, CK and desmin. Tumor cells showed low proliferative activity as demonstrates by low Ki-67 labelling index (5%). The tumor was diagnosed as a low-grade myxofibrosarcoma. Despite the suboptimal general conditions of the patient, yet, surgery was the sole treatment of her and was successfully done. Adjuvant radiotherapy was indicated due to close circumferential margin. Myxofibrosarcoma is a very rare tumor in the head and neck region, and morphology beside immunohistochemistry is powerful tools to establish the diagnosis. Surgery is the main line of treatment followed by adjuvant radiotherapy to improve patient's survival.

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“…12 Myofibroblastic sarcomas also present with spindle cells in a variable amount of myxoid matrix but are diagnostically positive for SMA and demonstrate myofilaments that ex-tend to the cell surface. 15 Distinction between MFS and LGFS is probably the most challenging. Although both MFS and LGFS are composed of alternating myxoid and fibrous stroma with spindle cells, the spindle cells in LGFS fall in a linear arrangement, which creates a swirling pattern.…”

Section: Discussionmentioning

confidence: 99%

Myxofibrosarcoma of the Maxillary Sinus

Wong

Park

Mirani

et al. 2017

Allergy�Rhinol (Providence)

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Background:Myxofibrosarcoma (MFS) is a common sarcoma in the extremities of older individuals but is extremely uncommon in the head and neck region. Diagnosis may be challenging but is critical to the management of the patient. We discuss the radiographic and histopathologic characteristics of this destructive tumor. The distinguishing features of MFS and its differential diagnosis are reviewed to familiarize the managing otolaryngologist with this rare entity.Methods:A 61-year-old woman presents with a 6-week history of severe left facial pain and left eye pain. Imaging demonstrates significant right and left-sided maxillary sinus opacification with destruction of the left maxillary sinus as well as the left medial and inferior orbital walls.Results:Histopathologic examination revealed spindle and stellate tumor cells of variable cellularity in myxoid stroma with cellular pleomorphism consistent with MFS of intermediate-to high grade. The patient underwent resection of the left-sided lesion with orbital exenteration and repair of the defect with microvascular free flap followed by postoperative radiotherapy.Conclusion:MFS must be differentiated from other lesions with myxoid qualities. Histopathologic examination is required for definitive diagnosis. Management includes complete tumor excision with adequate tumor margins. Adjuvant postoperative radiotherapy should be considered for larger tumors with positive resection margins or lesions of intermediate-to-high grade.

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Myxofibrosarcoma Arising in the Maxillary Sinus: A Case Report with a Review of the Ultrastructural Findings and Differential Diagnoses

Cited by 14 publications

References 48 publications

A Case of Myxofibrosarcoma in the Maxillary Sinus

A Case of Myxofibrosarcoma in the Maxillary Sinus

Myxofibrosarcoma of the Thyroid: Second Case in Africa

Myxofibrosarcoma of the Maxillary Sinus

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