Myxofibrosarcoma: Prognostic Factors and Survival in a Series of Patients Treated at a Single Institution

Sanfilippo, Roberta; Miceli, Rosalba; Grosso, Federica; Fiore, Marco; Puma, Elisa; Pennacchioli, Elisabetta; Barisella, Marta; Sangalli, Claudia; Mariani, Luigi; Casali, Paolo G.; Gronchi, Alessandro

doi:10.1245/s10434-010-1341-4

Cited by 220 publications

(261 citation statements)

References 12 publications

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“…Chemotherapy with doxorubicin and ifosfamide has been used in cases of tumor recurrence. MFSs have a better 5-year overall survival rate of 61% than other types of sarcoma [16,18]. In conclusion, we present a rare case of a retroperitoneal MFS in a middle-aged woman, with histopathological and immunohistochemical findings, to help differential diagnosis in future cases.…”

Section: Discussionmentioning

confidence: 87%

“…A local recurrence rate of 31% and a metastasis rate of 17% have been reported during the 3.5 years of follow-up post-surgery [16,17]. Lungs, bones, and lymph nodes are the most common metastatic sites of MFS [14,16,18]. Radical surgical eradication of the tumor with sufficient resection of surrounding margins is the recommended treatment option for MFS.…”

Section: Discussionmentioning

confidence: 99%

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Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Kim¹,

Suh²,

Kim³

et al. 2017

J Cytol Histol

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A 45-year-old previously healthy woman presented to our hospital with a right abdominal mass. Abdominal computed tomography (CT), magnetic resonance imaging, and bone scanning revealed a 15 cm×10 cm×14 cm, well-delineated, retroperitoneal tumor originating from the right kidney. No metastases detected. The patient underwent successful extirpation of the renal tumor. The tumor showed 50% necrosis without perirenal fat infiltration, and it was diagnosed as a high-grade (grade 3) myxofibrosarcoma without nodal positivity, according to the French Federation of Cancer Centers Sarcoma (FNCLCC) grading system. Tumor immunohistochemical staining revealed positive staining for CD34, Ki67, smooth muscle actin (SMA), and cluster of differentiation 68 (CD68), and negative staining for S100 protein, desmin, mast/stem cell growth factor receptor (c-kit), and melanoma marker antibody (HMB45). Three months post-surgery, follow-up CT revealed no new abdominal metastasis, and the patient is currently receiving routine follow-up without any additional systemic therapy. Myxofibrosarcoma of the kidney is an uncommon soft tissue tumor, and radical surgery is the treatment of choice. Long-term follow-up is recommended because of the tumor's aggressive invasiveness and potential for distant metastasis.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Kim¹,

Suh²,

Kim³

et al. 2017

J Cytol Histol

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“…These factors are not synonymous with prognostic factors although to a degree similar [4,26]. Since surgery remains the mainstay of extremity sarcoma and squamous cell carcinoma treatment, CDP scores may help in decisional practicalities such as to at what point in time to proceed with reconstruction, but not necessarily in deciding on different combinations of treatments or the scope of all treatments.…”

Section: Figurementioning

confidence: 99%

“…Modern imaging allows the adoption and utilization of surgical advantages provided by biological barriers of tumors (e.g., fascia, periosteum, cartilage). It also allows for the sparing of tissue which would have to be excised if one would follow extensive compartmental resections and may even allow for the use of some spared tissue for the reconstruction process [4,5,9,26,27].…”

Section: Figurementioning

confidence: 99%

Working with Orthopedic Oncologists: When to Offer Immediate and when and why to Delay Definitive Reconstruction of an Extremity

Dobke¹,

Mackert²,

Goldin³

et al. 2017

J Clin Exp Orthop

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A review of patients that were treated jointly by the plastic and the orthopedic surgery teams from 2011 to 2015 to evaluate the timing of definitive reconstruction of extremity defects was undertaken. The cohort consists of 81 patients, of which 4 presented with either a high-risk lesion or an advanced squamous cell carcinoma and of which the remaining 77 patients presented with different types of extremity sarcomas. In 58 cases, immediate-definitive reconstruction was performed, while in 23 cases the definitive procedure was delayed. Immediate definitive reconstruction, concurrent with ablative procedures, was offered whenever possible. In 16 cases, delayed reconstruction was due to diagnostic uncertainty (uncertain diagnosis per se or non-established negative margins). In 6 cases, delayed reconstruction was performed because of infection, in 1 case a bleeding disorder necessitated workup and in another, the intraoperative histology necessitated a plan-change, wound temporization and preparation of an arteriovenous fistula for microsurgical reconstruction. Indications for delayed reconstruction can be related to systemic conditions, donor or recipient site issues (infection, suspicion of margin-problems or tumor "not in continuity"). Although frozen sections have an overall diagnostic accuracy of 90%, changes in management were related to the inadequacy of frozen material, sampling errors resulting from heterogeneity or non-appositional growth of malignancy. A high rate (28%) of delayed reconstruction corresponds with new data reaffirming an old paradigm (radically excised margins "make a difference"), and with objectives dictated by customized, personalized, multimodal approaches. Wound temporization was offered whenever definitive reconstruction couldn't be performed immediately. Limb sparing, with the utilization of temporary spacers or distractors, mega-prostheses, or trials of reimplanting formerly tumorous bone autografts, which have been sterilized to eliminate malignant cells -may all necessitate temporary coverage or staged repair. Authors' clinical experience was evaluated in the context whether the rationale behind immediate versus delayed reconstruction was optimal.

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“…27,28 These tumors commonly arise in the extremities of elderly individuals. Unlike other sarcomas, when located superficially, the tumor infiltrates through soft tissue (subcutaneous fat and investing fascia) centimeters beyond the ostensible margins of the visible or palpable mass, even at initial presentation.…”

Section: Personalizing Surgerymentioning

confidence: 99%

Surgical management of localized soft tissue tumors

Gronchi

Colombo

Raut

2014

Cancer

Self Cite

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Soft tissue tumors are rare and can arise from a variety of soft tissues and viscera in a variety of body sites. Their management requires a thorough understanding of the biology of the different histologies and molecular subtypes as well as the constraints of specific anatomic sites. The surgical approach has undergone significant changes thanks to a better understanding of the natural history of the different histologic subtypes, the importance of site, and the different sensitivity to available drugs. The soft tissue tumor family includes 3 major, distinct categories: desmoid-type fibromatosis, soft tissue sarcoma, and gastrointestinal stromal tumor. In general, limb-sparing and function-sparing approaches should be used when feasible for tumors located in the extremities and girdles. Resections of adherent structures/viscera, which may be close but not invaded, may be needed in tumors arising in the retroperitoneum/abdomen to minimize microscopic intralesional margins, maximize local tumor control, and possibly improve survival. Margins of resection and the use of adjuvant/neadjuvant radiation therapy and/or chemotherapy are contingent on an accurate histologic diagnosis. Treatment planning should include multidisciplinary consultation to determine optimal therapy, taking into consideration tumor histology, site and extent of the disease, its natural history and sensitivity to available treatments, surgical challenges, and-of course-quality of life. Cancer 2014;120:2638-48.

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Myxofibrosarcoma: Prognostic Factors and Survival in a Series of Patients Treated at a Single Institution

Cited by 220 publications

References 12 publications

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Working with Orthopedic Oncologists: When to Offer Immediate and when and why to Delay Definitive Reconstruction of an Extremity

Surgical management of localized soft tissue tumors

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