Myxoid leiomyosarcoma of the liver

Leiomyomatous Tumors of the Hepatobiliary Tract

“…Histologically, the spindled myocytes form interlacing bundles embedded in a rich, Alcian blue-positive myxoid matrix. The mitotic activity was reported to be low (one per ten HPFs; Sicaja et al 2006). The clear aspect of the cytoplasm in one case was due to glycogen accumulation, as seen in electron microscopy (Sicaja et al 2006).…”

“…The mitotic activity was reported to be low (one per ten HPFs; Sicaja et al 2006). The clear aspect of the cytoplasm in one case was due to glycogen accumulation, as seen in electron microscopy (Sicaja et al 2006). Immunohistochemically, the tumor cells were positive for alpha-SMA and muscle-specific actin (HHF-35).…”

“…The tumor cells are reactive for muscle-specific actin, alpha-SMA, desmin, and vimentin ( Fig. 8; Watanabe et al 1991;Saint-Paul et al 1993;Dominguez Iglesias et al 1995;Higuchi et al 1995;Maruta et al 2004;Sicaja et al 2006). Smooth muscle tumors also express a unique pattern of gamma-smooth muscle isoactin gene expression (Brittingham et al 1997).…”

“…One variant of hepatic leiomyosarcoma is characterized by smooth muscle cells with a clear cytoplasm suspended in a myxoid stroma (hepatic myxoid leiomyosarcoma). Hepatic myxoid leiomyosarcoma was found in normal liver (Lee et al 2002;Tsiatis et al 2008) or in cirrhotic liver (Sicaja et al 2006). Myxoid leiomyosarcoma had originally been described as a distinct subtype in the uterus (King et al 1982).…”

Primäre Lebersarkome – Empfehlungen zur chirurgischen Therapie

“…1 Demografische, tumorspezifische Eigenschaften und Therapie der "häufigeren" primären Lebersarkome anhand der Literaturrecherche. Leiomyosarkom [190,191,192,193,194,195,196,197,198,199,200,201…”