Myxoid Leiomyosarcoma of the Uterus

Takano, Yoshinao; Morimura, Yutaka; Yamada, Hidekazu; Sato, Akira; Сузукі, Осаму; Suzuki, Toshimitsu

doi:10.5387/fms.46.41

“…Surgery remains the established treatment: total abdominal hysterectomy, with or without bilateral salpingo-oophorectomy, was performed in 24/27 cases (including ours); of the remaining three, two were treated with tumorectomy, and one patient received radiotherapy alone because of her cardiac condition. After surgery, adjuvant chemotherapy was administered to five patients (including ours); in a further five cases, chemotherapy was used to treat relapse (2)(3)(4)(5) . Although King et al (2) postulated that uterine myxoid leiomyosarcomas might not be responsive to chemotherapy or radiotherapy because of their low mitotic rate and the copious amount of intercellular myxomatous tissue, the effect of adjuvant therapy on preventing recurrence is still unclear (7,10) .…”

Section: Discussionmentioning

confidence: 99%

“…Although King et al (2) postulated that uterine myxoid leiomyosarcomas might not be responsive to chemotherapy or radiotherapy because of their low mitotic rate and the copious amount of intercellular myxomatous tissue, the effect of adjuvant therapy on preventing recurrence is still unclear (7,10) . Despite an aggressive therapeutic approach, local and systemic control is still a major problem, and recurrence is common: 17 of 24 followed-up patients experienced a recurrence from 3 months to 10 years after treatment, and the follow-up was longer than 3 years in only two of the seven women with no evidence of disease (2)(3)(4)(5) (3 years and 5 years 10 months in the patients reported by Sprogoe-Jakobsen and Holund (9) and Takano et al (5) , respectively). The most common sites of distant metastases were lung, liver, and brain (2,11) .…”

Section: Discussionmentioning

confidence: 99%

Massive myxoid leiomyosarcoma of the uterus

Vigone

¹

,

Giana

²

,

Surico

³

et al. 2005

Int J Gynecol Cancer

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Uterine myxoid leiomyosarcoma is a very rare and aggressive variant of uterine sarcoma, of which only 26 cases have been described in the literature published in English. A 59-year-old woman, who had been menopausal for 5 years and had a huge abdominal mass underwent laparotomy; histopathology of the bulky tumor revealed the particular characteristics of a myxoid leiomyosarcoma. Immunohistochemically, Ki-67 contributed toward indicating a malignancy, whereas p53 and progesterone and estrogen receptors were negative. The level of serum Ca125 was high at diagnosis, within normal limits after the fifth cycle of chemotherapy, and subsequently increased again at recurrence. Sixteen months after surgery, the patient died of respiratory failure. Immunohistochemistry and Ca125 levels can aid the diagnosis, management, and prognosis of uterine myxoid leiomyosarcoma.

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“…Typical uterine myomas may or may not coexist in the terus; Mittal reported a case of myxoid leiomyosarcoma arising in a myoma (6) . The myxoid leiomyosarcomas were usually large, with 16 having a mean diameter of >8 cm (2–5) . In our case, the tumor filled the entire abdominal cavity and weighed 6 350 g.…”

Section: Discussionmentioning

confidence: 55%

“…Myxoid leiomyosarcoma of the uterus is an extremely uncommon and aggressive neoplasm, with a poor prognosis. Its rarity has led to problems in diagnosis and management by pathologists, gynecologists, and oncologists: only 26 cases have been reported in the literature since it was first described by King et al in 1982 (2–5) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Massive myxoid leiomyosarcoma of the uterus

Vigone¹,

Giana²,

Surico³

et al. 2005

Int J Gynecol Cancer

View full text Add to dashboard Cite

Uterine myxoid leiomyosarcoma is a very rare and aggressive variant of uterine sarcoma, of which only 26 cases have been described in the literature published in English. A 59-year-old woman, who had been menopausal for 5 years and had a huge abdominal mass underwent laparotomy; histopathology of the bulky tumor revealed the particular characteristics of a myxoid leiomyosarcoma. Immunohistochemically, Ki-67 contributed toward indicating a malignancy, whereas p53 and progesterone and estrogen receptors were negative. The level of serum Ca125 was high at diagnosis, within normal limits after the fifth cycle of chemotherapy, and subsequently increased again at recurrence. Sixteen months after surgery, the patient died of respiratory failure. Immunohistochemistry and Ca125 levels can aid the diagnosis, management, and prognosis of uterine myxoid leiomyosarcoma.

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The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N‐acetylglucosaminyltransferase V

Wang

¹

,

Li

²

,

Yang

³

et al. 2009

J of Cellular Biochemistry

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N-acetylglucosaminyltransferase V (GnT-V) has been reported to be positively associated with tumor progression, but its mechanism still remains unknown. In the present study, we found that GnT-V overexpression not only changed the glycosylation of receptor protein tyrosine phosphatase kappa (RPTPkappa) but also decreased its protein level. Moreover, GnT-V overexpression decreased cell calcium-independent adhesion and increased the tyrosine phosphorylation level of beta-catenin, in which RPTPkappa played an important role. Since RPTPkappa has an RXKR motif, which is a favored cleavage site for furin, we used furin inhibitor to further explore the effect of RPTPkappa on the change of cell adhesion and beta-catenin signaling induced by GnT-V. Our results showed that preventing RPTPkappa cleavage rescued the above effects of GnT-V, suggesting that furin cleavage could be one of the factors for RPTPkappa to regulate cell adhesion and beta-catenin signaling in GnT-V overexpression cell lines. In addition, the increased tyrosine phosphorylation level of beta-catenin was associated with the increased nuclear level of beta-catenin and downstream signaling molecules such as c-myc and cyclin D1 that were associated with cell proliferation. Our results suggest that GnT-V could decrease human hepatoma SMMC-7721 cell adhesion and promote cell proliferation partially through RPTPkappa.

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Myxoid Leiomyosarcoma of the Uterus

Cited by 9 publications

References 12 publications

Massive myxoid leiomyosarcoma of the uterus

Massive myxoid leiomyosarcoma of the uterus

Massive myxoid leiomyosarcoma of the uterus

The effect of receptor protein tyrosine phosphatase kappa on the change of cell adhesion and proliferation induced by N‐acetylglucosaminyltransferase V

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