Myxoid neurofibroma: An unusual presentation

Ponce-Olivera, Rosa María; Tirado‐Sánchez, Andrés; Peniche-Castellanos, Amelia; Peniche-Rosado, Jorge; Mercadillo-Pérez, Patricia

doi:10.4103/0019-5154.39742

Cited by 14 publications

(7 citation statements)

References 4 publications

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“…27 Myxoid neurofibroma is a tumor with myxoid characteristics that can be located in a wide variety of sites and stains positive for S-100 and negative for desmin, whereas AA is S-100 negative and desmin positive. 28 Myxoid liposarcoma is a malignant tumor composed of primitive nonlipogenic mesenchymal cells and lipoblasts with no hormone receptors on the cell surface. 29 Cellular angiofibroma is a more cellular tumor with well-circumscribed margins, usually occurring in subcutaneous locations.…”

Section: Discussionmentioning

confidence: 99%

Aggressive Angiomyxoma of the Pelvis: 35-year Experience

Cardenas Lara,

Bauzon,

Perry

et al. 2023

Diseases of the Colon &Amp; Rectum

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BACKGROUND: Aggressive angiomyxoma is a very rare mesenchymal tumor most commonly found in the pelvic and perineal regions. Although many are estrogen and progesterone hormone receptor positive, the pathogenesis is unknown. Due to the rarity, there is a paucity of literature relating to this pathology. This paper presents a case-series on the management of aggressive angiomyxoma of the pelvis. OBJECTIVE: To present a 35-year experience managing aggressive angiomyxoma of the pelvis. DESIGN: This was a retrospective single system analysis. SETTINGS: This study was conducted at a quaternary referral academic healthcare system. PATIENTS: All patients treated for aggressive angiomyxoma of the pelvis. INTERVENTIONS: All patients underwent surgical and/or medical management of their disease. MAIN OUTCOME MEASURES: The primary outcomes were disease recurrence and mortality. Secondary outcomes included risk factors for recurrence. RESULTS: A total of 32 patients (94% female) were identified with a median follow-up of 65 months. Thirty (94%) underwent operative resection and 2 were treated solely with medical management. Fifteen achieved an R0 resection (negative microscopic margins) at the index operation, of which 4 (27%) experienced tumor recurrence. There were no mortalities. No risk factors for disease recurrence were identified. LIMITATIONS: Limitations to our study include its nonrandomized retrospective nature, single healthcare system experience, and small patient sample size. CONCLUSIONS: Aggressive angiomyxoma is a rare, slow-growing tumor with locally invasive features and high potential for recurrence even after resection with negative margins. Imaging modalities such as CT and/or MRI should be obtained to aid in diagnosis and surgical planning. Workup should be paired with preoperative biopsy and testing for hormone receptor status, which can increase diagnostic accuracy and guide medical treatment. Close post-treatment surveillance is imperative to detect recurrence. See Video Abstract.

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Section: Discussionmentioning

confidence: 99%

Aggressive Angiomyxoma of the Pelvis: 35-year Experience

Cardenas Lara,

Bauzon,

Perry

et al. 2023

Diseases of the Colon &Amp; Rectum

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“…[2] Myxoid neurofibroma is poorly circumscribed and an unencapsulated lesion, which lacks lobular architecture and shows patchy S-100 positivity. [7] Myxoid schwannoma shows foci of Antoni A with Verocay bodies. They do not show multinodularity but express S-100.…”

Section: Discussionmentioning

confidence: 99%

Nerve sheath myxoma of scalp: A rare site of presentation

et al. 2019

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Nerve sheath myxoma, a superficial myxoid tumor, was first described in 1969 by Harkin and Reed. Tumor has cytological and histological resemblance with neurothekeoma, another cutaneous myxoid lesion. Nerve sheath myxoma affects individuals of all age groups and equal predilection for both genders with most favored sites being the fingers and knee. Here, we present a case report of nerve sheath myxoma of the scalp, diagnosed and confirmed with histopathology and immunohistochemistry.

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“…These tumours are confused often clinically and histopathologically with myxomas. Myxomas have no nerve involvement and are S100 negative [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common locations are the face, shoulder, anus, periungal, and in the feet. Only one case occurring in the trunk is reported [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Solitary Giant Intramuscular Myxoid Neurofibroma Resulting in an above Elbow Amputation

Chennakeshaviah

Ravishankar

Rangaswamy

et al. 2012

Case Reports in Pathology

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Neurofibromas are uncommon benign tumours and are still rarer in intramuscular locations. They are not detected until they cause a significant damage to the neighbouring tissues. We present a case of a giant intramuscular myxoid neurofibroma of the left forearm which eroded the radius and ulna, restricting the movements at the elbow and wrist joints and causing wrist drop resulting in an above elbow amputation. It was diagnosed by histopathology and was later confirmed by immunohistochemistry.

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Myxoid neurofibroma: An unusual presentation

Cited by 14 publications

References 4 publications

Aggressive Angiomyxoma of the Pelvis: 35-year Experience

Aggressive Angiomyxoma of the Pelvis: 35-year Experience

Nerve sheath myxoma of scalp: A rare site of presentation

Solitary Giant Intramuscular Myxoid Neurofibroma Resulting in an above Elbow Amputation

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