Myxoid Solitary Fibrous Tumor on the Scalp

Kim, Ji Hyun; Kim, Dong Chul; Lee, Ryun; Shin, Chi Ho; Han, Yea Sik; Chung, Sang Hun; Paik, So Ya

doi:10.7181/acfs.2017.18.4.269

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…The clinical behavior of SFTs is variable, with local recurrences as well as rare distant metastases. Tumor size > 10cm, increased cellularity, mitotic count > 4/10 HPFs, atypical mitoses, nuclear pleomorphism and necrosis are associated with recurrence and metastasis [11]. Molecular attributes like telomerase reverse transcriptase (TERT) gene promoter mutations and TP53 mutations are also associated with tumor aggressiveness [1].…”

Section: Discussionmentioning

confidence: 99%

Myxoid Solitary Fibrous Tumor of the Nasal Vestibule: An unusual histological subtype in the Head and Neck region

Prabakaran,

Kakkar,

Jain

et al. 2024

Preprint

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Introduction: Solitary fibrous tumors (SFTs) are mesenchymal neoplasms associated with characteristic NAB2::STAT6 gene fusion. They frequently occur in extra-thoracic sites but are not uncommon in the head and neck (HN) region where 10–20% of all SFTs occur. Around 10% of HNSFTs recur, usually following incomplete resection. Myxoid SFT is a rare morphologic subtype of SFT, the features of which overlap with those of other myxoid-appearing tumors, making the diagnosis challenging. Objective To describe the distinctive histopathological and immunohistochemical features of myxoid SFT that aid in diagnosis Materials and Methods This 32-year-old male presented with a recurrent swelling in the nasal vestibule, which had previously been excised four years prior and diagnosed as neurofibroma. Examination revealed a firm swelling measuring 2x1cm. Results Histological examination showed a nodular tumor composed of short spindle shaped cells in an abundant myxoid stroma. Nuclei were ovoid, with minimal pleomorphism. Occasional intervening slender vascular channels were present; staghorn vasculature was absent. Tumor cells were diffusely immunopositive for STAT6, CD34 and Bcl-2, while S100, SOX10, EMA, ER and CD10 were negative, confirming the diagnosis of myxoid SFT. Conclusion Myxoid SFTs are unusual in the HN, with potential for misdiagnosis. Due to their propensity for local recurrence if incompletely excised, a high index of suspicion is required to include them in differential diagnosis of myxoid mesenchymal neoplasms occurring at this location. STAT6 is a reliable immunohistochemical marker that aids in diagnosis, reducing the necessity for molecular testing.

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Section: Discussionmentioning

confidence: 99%

Myxoid Solitary Fibrous Tumor of the Nasal Vestibule: An unusual histological subtype in the Head and Neck region

Prabakaran,

Kakkar,

Jain

et al. 2024

Preprint

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“…Cutaneous SFT is an extremely rare neoplasm, presenting as a painless, superficial, and well-circumscribed mass that can be confused clinically with lipoma or epidermal cyst [3]. A summary of previously reported cases of scalp SFT and the current one is illustrated in Table 1 [13][14][15][16][17][18][19][20][21][22][23][24]. Confirming a diagnosis of unusual skin and soft tissue mass lesions, including SFT, is challenging and requires careful sampling of the tumor mass followed by careful pathological examination [25,26].…”

Section: Discussionmentioning

confidence: 99%

Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review

Rabie

Hasan

Mohammed

et al. 2022

J Pathol Transl Med

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Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm that first was discovered in the pleura but can also affect the peritoneum, lungs, mediastinum, and skin. Cutaneous malignant SFT is an extremely rare tumor that resembles dermatofibrosacoma protuberance (DFSP) histologically and immunohistochemically. Herein, we describe a case of malignant SFT that presented as a recurrent mass on the scalp. The first lesion was totally excised one year before recurrence and was diagnosed as a DFSP based on the histopathology and cluster of differentiation 34 immunostaining positivity. Re-examination of the previously examined specimen was considered. Activator of transcription 6 positivity was also detected in the tissue, confirming the diagnosis of a recurrent malignant SFT rather than DFSP. There was no evidence of recurrence, locoregional, or distant metastases at six months after lesion removal with a safety margin.

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“…A A B B about 6.5% of SFT cases are be malignant [17]. SFT with a scalp origin is very rare, with just 16 cases reported previously [6][7][8][9][18][19][20][21]. As with SFT at other sites, malignant SFTs of the scalp are rare, with just two cases reported.…”

Section: Fig 3 the Resected Superior Portion Of Mass With Abnormal Sc...mentioning

confidence: 99%

“…The pathological characteristics of SFT include nodular spindle-cell proliferation, and specific immunoreactive stains are helpful for diagnosis. Among the various sites of origin, SFT originating from the scalp has been reported in 16 cases [6][7][8][9]. In contrast, malignant SFTs with a scalp origin are extremely rare, with only two cases reported in the literature [10,11].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp

Kim,

Kim

2023

Keimyung Med J

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Solitary fibrous tumor (SFT) is an uncommon tumor that typically originates in the pleural cavity but may also be found in extra-pleura sites like the head and neck, spine, lungs, mediastinum, peritoneum, and pelvis. There are few reports of SFT of the scalp, and malignant SFT of the scalp appears to be so rare that only two cases of it were reported previously. A 47-year-old woman was admitted to our institution with a large, rapidly growing mass on the left parietal scalp. An analysis of her scalp condition and imaging findings of the mass revealed two different appearances between the superior and inferior halves; the scalp of the inferior half looked normal, but that of the superior half did not. Also, computed tomography findings of the mass confirmed different patterns between the superior and inferior halves. The mass with the abnormal superior half scalp was removed totally. The pathological diagnosis was malignant SFT, but the inferior mass was revealed to have a benign nature. The patient underwent prophylactic radiotherapy and experienced no local recurrence or distant metastasis at the final follow-up at 12 months. We present a third case of malignant SFT originating on the scalp and describe our clinical and surgical experience managing malignant SFT of the scalp.

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Myxoid Solitary Fibrous Tumor on the Scalp

Cited by 6 publications

References 10 publications

Myxoid Solitary Fibrous Tumor of the Nasal Vestibule: An unusual histological subtype in the Head and Neck region

Myxoid Solitary Fibrous Tumor of the Nasal Vestibule: An unusual histological subtype in the Head and Neck region

Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review

A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp

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