Myxoid solitary fibrous tumour of the axilla

Myxoid solitary fibrous tumor: a clinicopathologic study of three cases

“…In contrast, solitary fibrous tumors exhibiting a predominantly myxoid stroma are rarely encountered. Since the initial series of myxoid solitary fibrous tumors described by de Saint Aubain Somerhausen et al [6], only seven additional cases of this entity have been reported (Table 3) [7][8][9][10][11][12][13]. The histologic features of myxoid solitary fibrous tumor are relatively nonspecific and include the presence of abundant, pale myxoid matrix, thin-walled stromal blood vessels, and haphazardly arranged, cytologically bland spindle cells.…”

“…The relationship between these pathologic variables and biologic behavior is imperfect, however, as some solitary fibrous tumors exhibiting the aforementioned atypical features have pursued a benign course, while others lacking such features have behaved aggressively [4,5,[23][24][25][26]. There is considerably less information available concerning the clinical behavior of the myxoid variant of solitary fibrous tumor, which is largely attributable to the rarity of this neoplasm, and the relative absence of extended clinical follow-up in reported cases of this entity [6][7][8][9][10][11][12][13]. Among three cases of myxoid solitary fibrous tumor comprising the present series, none were associated with local or distant relapse, with follow-up ranging from 50 to 87 months.…”

“…Cases of myxoid solitary fibrous tumor described to date have been similarly largely devoid of features of biologic aggressiveness [7][8][9][10][11][12][13], with the exception of three tumors in one series which were more than 10 cm in size [6]. No follow-up information was available in two cases, while in the third, the patient showed no evidence of recurrent disease at 27 months follow-up.…”

“…In contrast, the biologic behavior of myxoid solitary fibrous tumor has not been determined due to the limited number of reported cases of this entity and relatively short duration of follow-up [6][7][8][9][10][11][12][13]. In order to expand on the clinical, morphologic, and immunophenotypic characterization of this uncommon variant of solitary fibrous tumor, three additional cases of myxoid solitary fibrous tumor with long-term clinical follow-up are reported herein.…”

“…While focal myxoid change is a not an uncommon finding in solitary fibrous tumor [3][4][5], solitary fibrous tumors characterized by a prominent myxoid stroma are quite rare. To date, less than 15 cases of myxoid solitary fibrous tumor have been reported in the literature [6][7][8][9][10][11][12][13].…”