n-3 and n-6 Fatty Acid Changes in the Erythrocyte Membranes of Patients with &lt;I&gt;Clostridium difficile&lt;/I&gt; Infection

Czepiel, Jacek; Gdula‐Argasińska, Joanna; Garlicki, Aleksander

doi:10.3409/fb64_1.3

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Typically, n-6 is thought to have pro-inflammatory effects. 73 In our study, a positive correlation was found between DII score and the proportion of erythrocyte membrane n-6 in OB group, after adjustment for model 2 ( P <0.05). The pro-inflammatory effect of n-6 is mainly related to C20:4 n-6.…”

Section: Discussionsupporting

confidence: 50%

“…Competitive metabolism exists between n-3 and n-6 polyunsaturated fatty acids, whereas n-3 is generally considered to have anti-inflammatory effects, and a higher n-6/n-3 ratio in the diet is related to inflammation and multiple chronic diseases. 73,75 Our study found that DII scores were positively correlated with the proportion of the ratio of n-6 and n-3 of the erythrocyte membranes in OB group regardless of the adjusted models (P<0.05).…”

Section: Discussionmentioning

confidence: 62%

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Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years

Huang,

Li,

Shen

et al. 2024

JIR

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Background and Objective Cognitive dysfunction is highly prevalent in obese people, and food is a key factor in obesity, and dietary inflammatory index (DII) can reflect whether diet has anti-inflammatory or pro-inflammatory potential. In addition, dietary fatty acid consumption is linked to inflammation, obesity, and cognitive impairment. Erythrocyte membrane fatty acids can reflect dietary fatty acid intake. Our hypothesis was that erythrocyte membrane fatty acids might have a significant impact on the relationship between DII and cognition in obese individuals, and we designed experiments to test the hypothesis. Methods In three villages in Beijing, we collected 579 respondents from individuals 45 to 75 years old and categorized them by body mass index. The Montreal Cognitive Assessment (MoCA) score and DII score was calculated and gas chromatography was used to measure the proportion of erythrocyte membrane fatty acids. The relationship between the DII score and cognition was examined using multiple linear regression and binary logistic regression. Mediation analysis can help to understand the causal chain between variables, deeply explore the internal relationship and mechanism of action between variables. So a multiple chain mediation model was developed to investigate the mediating factors between the DII score and cognitive association. Results According to adjusted linear regression, higher DII scores were linked to lower MoCA scores in the obese group. The negative correlation between DII score and cognitive function score remains in binary linear regression. We discovered through mediation analysis that erythrocyte membrane fatty acids mediate the detrimental link between DII and cognitive function in obese individuals. Conclusion We propose that higher DII scores in obese people are associated with a decline in cognitive function. In addition, this effect might be mediated via the fatty acids in the erythrocyte membrane.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 62%

Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years

Huang,

Li,

Shen

et al. 2024

JIR

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“…So far, the role of FA and their derivatives in the course of infection has been demonstrated (Shaikh and Edidin 2008 ; Tiesset et al 2009 ; Czepiel et al 2016 ), but there are no studies assessing this effect during neuroinfection. Moreover, the concentration of FA and ECB in neuroinfections was never directly assessed in the material taken from the CNS.…”

Section: Introductionmentioning

confidence: 99%

Fatty acids and selected endocannabinoids content in cerebrospinal fluids from patients with neuroinfections

et al. 2018

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Neuroinfections are a significant medical problem and can have serious health consequences for patients. Their outcome, if not fatal, can be associated with permanent residual deficits. Cerebrospinal fluid (CSF) examination is commonly used for meningitis confirmation. Fatty acids (FA) are precursors of lipid mediators with pharmacological activity. They actively modulate inflammation as well as contribute to its resolution. Therefore the aim of this study was to determine the FA and selected endocannabinoids (ECB) content in the CSF obtained from patients with bacterial (BM) and viral meningitis (VM) using chromatographic techniques. A significantly lower level of saturated FA was found in patients with BM and VM as compared to controls. There was a significantly higher concentration of long-chain monounsaturated FA and polyunsaturated n-6 FA in the CSF obtained from patients with neuroinfection. Moreover, a significant reduction of n-3 FA in CSF obtained from patients with BM and VM was demonstrated. The highest amount of ECB was detected in the CSF of patients with VM: eicosapentaenoyl ethanolamide (1.65 pg/mL), docosahexaenoyl ethanolamide (655.5 pg/mL) and nervonoyl ethanolamide (3.09 ng/mL). Results indicate the participation of long-chain monounsaturated and polyunsaturated FA and their derivatives in the inflammatory process and likely in the process of resolution of inflammation during neuroinfection. It seems that the determination of the FA and ECB profile in CSF may be a valuable biomarker of health and may allow the development of new pharmacological strategies, therapeutic goals and fatty acids supplementation necessary in the fight against inflammation of the central nervous system.

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Clostridium difficile caused changes in fatty acids profile and resolvin D1 content in plasma of infected patients

Dróźdź¹,

Gdula‐Argasińska²,

Biesiada³

et al. 2020

European Journal of Gastroenterology &Amp; Hepatology

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Objectives Clostridium difficile infection (CDI) is an acute gastrointestinal infection caused by anaerobic, toxin-producing bacteria. During the course of CDI, there is a general inflammatory state. In order to gain a deeper understanding of the role of fatty acids (FAs) in the pathogenesis of acute infection we analyzed their plasma content in both patients with CDI and controls. Methods The study groups included 40 patients with CDI and 40 healthy volunteers. Plasma FA content was analyzed by gas chromatography, resolvin D1 (RvD1) level using ELISA assay, and we assessed the white blood cell (WBC) count, neutrophil count and C-reactive protein (CRP) level. Results Patients with CDI were characterized by significantly higher values of WBC, neutrophils, platelets and CRP compared with the control group. The saturated FA index was statistically higher and total n-3 FA was significantly decreased in the plasma of CDI patients as compared with the control group. RvD1 content was significantly higher in the control group as compared with patients with CDI. Conclusion In patients with good outcomes, we probably observed the effective resolution of inflammation, as reflected in n-3 FA metabolism and their significant decrease in plasma. This may indicate the therapeutic role of n-3 FA in CDI infection.

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n-3 and n-6 Fatty Acid Changes in the Erythrocyte Membranes of Patients with <I>Clostridium difficile</I> Infection

Cited by 4 publications

References 28 publications

Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years

Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years

Fatty acids and selected endocannabinoids content in cerebrospinal fluids from patients with neuroinfections

Clostridium difficile caused changes in fatty acids profile and resolvin D1 content in plasma of infected patients

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