2008
DOI: 10.1093/ajcn/87.6.2003s
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n−3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects

Abstract: Dietary nҀ3 fatty acids, particularly eicosapentaenoic acid and docosahexaenoic acid, are important nutrients through the life cycle. Evidence from observational, clinical, animal, and in vitro studies indicates a beneficial role of nҀ3 fatty acids in the prevention and management of cardiovascular disease. Although the precise mechanisms are still unclear, clinical and preclinical studies indicate that the cardioprotective effects of nҀ3 fatty acids may be attributed to a number of distinct biological effects… Show more

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Cited by 83 publications
(62 citation statements)
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“…Also, in animal models, n3 PUFA supplementation has been shown to enhance ( 72 ) or prevent the reduction in ERG a-and b-wave amplitudes after transient ischemia ( 73,74 ). Dietary n3 PUFAs have also been shown to be effective in suppressing infl ammation and in reducing the incidence of arteriosclerosis and heart failure by lowering plasma triglycerides and blood pressure ( 75,76 ). Thus, we evaluated which of the LC-PUFAs are metabolically active precursors for the synthesis of VLC-PUFA using cell cultures as a fi rst step to eventually determine whether dietary supplementation of these FAs could provide benefi cial effects to STGD3 patients, as has been shown for AMD patients in some of the Age-Related Eye Disease Study (AREDS) studies ( 37,39 ).…”
Section: Discussionmentioning
confidence: 99%
“…Also, in animal models, n3 PUFA supplementation has been shown to enhance ( 72 ) or prevent the reduction in ERG a-and b-wave amplitudes after transient ischemia ( 73,74 ). Dietary n3 PUFAs have also been shown to be effective in suppressing infl ammation and in reducing the incidence of arteriosclerosis and heart failure by lowering plasma triglycerides and blood pressure ( 75,76 ). Thus, we evaluated which of the LC-PUFAs are metabolically active precursors for the synthesis of VLC-PUFA using cell cultures as a fi rst step to eventually determine whether dietary supplementation of these FAs could provide benefi cial effects to STGD3 patients, as has been shown for AMD patients in some of the Age-Related Eye Disease Study (AREDS) studies ( 37,39 ).…”
Section: Discussionmentioning
confidence: 99%
“…Currently, many factors are considered involved in the beneficial cardiovascular effects of fish oil n-3 fatty acids (8)(9)(10) and soy products (11)(12)(13), including reduced blood pressure (14,15). Evidence suggests that nitric oxide (NO) plays a major role in regulating blood pressure and that impaired NO bioactivity is an important component of hypertension (16) Furthermore, increase in NO has been reported as one of the pathophysiological mechanisms implicated in reducing blood pressure using fish oil n-3 fatty acids (14,17) or soy products (15).…”
mentioning
confidence: 99%
“…37 Balık ve deniz ürünlerinde bol miktarda bulunan ÇDYA'dan olan n-3 yağ asitleri de trigliserid, toplam kolesterol ve LDL-K seviyelerini azaltabilmekte, HDL-K seviyesini ise artırabilmektedir. 38 TDYA alımı plazma LDL-K düzeylerinde azalma ve HDL-K düzeylerinde artış ile ilişkili olduğu gibi, oleattan zengin LDL-K'nın linoleattan zengin LDL-K'ya göre oksidasyona daha az yatkın olduğu gösterilmiştir. 39 TDYA'dan zengin diyet; hücre membranında yeterli akışkanlığı sağlayarak lipit peroksidasyon riskini azaltabilmektedir.…”
Section: Doymamış Yağlarunclassified