2007
DOI: 10.2337/db06-1206
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n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Abstract: Recent studies have suggested that n-3 fatty acids, abundant in fish oil, protect against high-fat diet-induced insulin resistance through peroxisome proliferator-activated receptor (PPAR)-␣ activation and a subsequent decrease in intracellular lipid abundance. To directly test this hypothesis, we fed PPAR-␣ null and wild-type mice for 2 weeks with isocaloric high-fat diets containing 27% fat from either safflower oil or safflower oil with an 8% fish oil replacement (fish oil diet). In both genotypes the saffl… Show more

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Cited by 208 publications
(174 citation statements)
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“…Interestingly, and in accordance with previous studies, neither treatment by DHA/EPA [11,12,18], nor rosiglitazone alone (at the relatively low dose used) [23], significantly affected the rate of glycogen synthesis [34]. Increased insulin sensitivity of skeletal muscle is further supported by changes in Akt/PKB phosphorylation.…”
Section: Discussionsupporting
confidence: 89%
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“…Interestingly, and in accordance with previous studies, neither treatment by DHA/EPA [11,12,18], nor rosiglitazone alone (at the relatively low dose used) [23], significantly affected the rate of glycogen synthesis [34]. Increased insulin sensitivity of skeletal muscle is further supported by changes in Akt/PKB phosphorylation.…”
Section: Discussionsupporting
confidence: 89%
“…However, n-3 LC-PUFA appear to have little effect on glycaemic control in diabetic patients [4,6,7]. In rodents fed a high-fat diet, n -3 LC-PUFA efficiently prevented development of obesity [8][9][10] and of impaired glucose tolerance (IGT) [11,12].…”
Section: Introductionmentioning
confidence: 99%
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