n-3 fatty acids reduce plasma 20-hydroxyeicosatetraenoic acid and blood pressure in patients with chronic kidney disease

Barden, Anne; Burke, Valerie; Mas, Emilie; Beilin, Lawrence J.; Puddey, Ian B.; Watts, Gerald F.; Irish, Ashley; Mori, Trevor A.

doi:10.1097/hjh.0000000000000621

Cited by 28 publications

(17 citation statements)

References 34 publications

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“…The remaining 278 references could be utilized to establish the increase in 8-iso-PGF 2α levels associated with medical conditions [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146]…”

Section: Resultsmentioning

confidence: 99%

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Erve

2018

Redox Biology

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The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. However, there is still no systemic assessment of the efficacy of treatments for oxidative stress reduction across a variety of medical conditions.The goal of this meta-analysis is, by combining multiple studies, to quantitate the change in the levels of the popular oxidative stress biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α) after a variety of treatment strategies in human populations.Nearly 350 unique publications with 180 distinct strategies were included in the analysis. For each strategy, the difference between pre- or placebo and post-treatment levels calculated using Hedges’ g value of effect. In general, administration of antibiotics, antihyperlipidemic agents, or changes in lifestyle (g = − 0.63, − 0.54, and 0.56) had the largest effect. Administration of supplements, antioxidants, or changes in diet (g = − 0.09, − 0.28, − 0.12) had small quantitative effects. To fully interpret the effectiveness of these treatments, comparisons to the increase in g value for each medical condition is required. For example, antioxidants in populations with coronary artery disease (CAD) reduce the 8-iso-PGF2α levels by g = − 0.34 ± 0.1, which is quantitatively considered a small effect. However, CAD populations, in comparison to healthy populations, have an increase in 8-iso-PGF2α levels by g = 0.38 ± 0.04; therefore, the overall reduction of 8-iso-PGF2α levels is ≈ 90% by this treatment in this specific medical condition.In conclusion, 8-iso-PGF2α levels can be reduced not only by antioxidants but by many other strategies. Not all strategies are equally effective at reducing 8-iso-PGF2α levels. In addition, the effectiveness of any strategy can be assessed only in relation to the medical condition investigated.

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Section: Resultsmentioning

confidence: 99%

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Erve

2018

Redox Biology

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“…Clinical epidemiological studies have demonstrated a significant association between reduced n -3 PUFA consumption and the risk of ischemic heart disease [ 24 ], suggesting that n -3 PUFA replacement may improve clinical outcomes in high-risk populations. In patients undergoing chronic hemodialysis, n -3 PUFA reduce all-cause mortality [ 25 ], the incidence of myocardial infarction [ 26 ] and improves blood pressure [ 27 ]. However, their impact on endothelial dysfunction, an early marker of cardiovascular disease is currently unknown in this setting.…”

Section: Discussionmentioning

confidence: 99%

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

et al. 2017

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Background: Endothelial dysfunction is a key vascular alteration in chronic kidney disease (CKD). Omega 3 (n-3) polyunsaturated fatty acids (PUFA) reduce vascular oxidative stress and inflammation. We investigated whether n-3 PUFA could reverse endothelial dysfunction in CKD by improving endothelial nitric oxide synthase (eNOS) function and oxidative stress. Methods: 5/6 nephrectomized male Wistar rats (CKD; n = 10) and sham operated animals (SHAM; n = 10) were treated for 6 weeks with standard diet. An additional group of CKD rats were fed an n-3 PUFA enriched diet (CKD + PUFA; n = 10). We then measured endothelium-dependent (EDD) and -independent vasodilation, markers of endothelial function and of oxidative stress in thoracic aortas. Results: Compared to SHAM, in CKD aortas EDD and eNOS expression were reduced (p < 0.05) and 3-nitrotyrosine levels were increased, while expression of NADPH oxidase subunits NOX4 and p22phox was similar. In-vitro incubation with Tiron failed to reverse endothelial dysfunction in CKD. In CKD + PUFA, EDD improved (p < 0.05) compared with CKD rats, while blockade of eNOS by L-NAME worsened EDD. These effects were accompanied by increased (p < 0.05) eNOS and reduced (p < 0.05) expression of NOX4 and 3-nitrotyrosine levels. Conclusion: Collectively, these findings indicate that n-3 PUFA improve endothelial dysfunction by restoring NO bioavailability in CKD.

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“…High ratios of n-3/n-6 play an important role in human health as these prevent and reduce human cardiovascular diseases [36,75], which represent the second cause of death in France after cancer [76]. Indeed, n-3 PUFA reduces cardiac frequency [62,63], (improves vascular function, reduces plasma 20-hydroxyeicosatetraenoic acid and blood pressure in patients with chronic kidney disease) [77]. Furthermore, in the present study, it prevents human coronary diseases [78], increases sensitivity to insulin [79], and reduces arterial stiffness [80].…”

Section: Fatty Acidsmentioning

confidence: 99%

Trace Elements and Fatty Acid Profile of Argyrosomus regius (Asso, 1801) from Mediterranean Aquaculture

Amoussou

Marengo

Durieux

et al. 2019

Biol Trace Elem Res

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Although Argyrosomus regius (Asso, 1801) counts among the most appreciated and increasingly consumed fish species in Europe, little information is available on its flesh quality. This research concerns both healthy aquatic resource diversification and good nutritional quality. It is the first study to evaluate the quality of A. regius flesh from Mediterranean aquaculture. It aims to assess the concentration of 19 trace elements and to determine the fatty acid profile of this fish farmed in the Mediterranean Sea and to discuss human exposure risks. The nutritional intake of oligoelements (selenium (Se), zinc (Zn), and chromium (Cr)) and the mean concentrations of contaminants (arsenic (As), barium (Ba), cadmium (Cd), lead (Pb), and tin (Sn)) in A. regius muscles are, respectively, above and below recommended regulatory standards set by the international legislation. Additionally, the low fat content in its muscle mass and its high level of docosahexaenoic acid (C22: 6 n-3; DHA) and, to a lesser extent, eicosapentaenoic acid (C20: 5 n-3; EPA) confers satisfying nutritional qualities. This study allowed to conclude that meager can be considered as a source of seafood with good nutritional qualities for human health.

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n-3 fatty acids reduce plasma 20-hydroxyeicosatetraenoic acid and blood pressure in patients with chronic kidney disease

Abstract: This is the first report that n-3 fatty acid supplementation reduces plasma 20-HETE in humans and that this associates with reduced BP. These results provide a plausible mechanism for the reduction in BP observed in patients with CKD following n-3 fatty acid supplementation.

Cited by 28 publications

References 34 publications

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Strategies to decrease oxidative stress biomarker levels in human medical conditions: A meta-analysis on 8-iso-prostaglandin F2α

Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Trace Elements and Fatty Acid Profile of Argyrosomus regius (Asso, 1801) from Mediterranean Aquaculture

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