2000
DOI: 10.1074/jbc.275.2.721
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n-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation

Abstract: This study describes specific molecular mechanisms by which supplementation with n-3 fatty acids (i.e. those present in fish oils) can modulate the expression and activity of degradative and inflammatory factors that cause cartilage destruction during arthritis. Our data show that incorporation of n-3 fatty acids (but not other polyunsaturated or saturated fatty acids) into articular cartilage chondrocyte membranes results in a dose-dependent reduction in: (i) the expression and activity of proteoglycan degrad… Show more

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Cited by 242 publications
(155 citation statements)
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“…Supplementing with 50-100 µg/mL omega-3 PUFAs, reduces the expression and activity of aggrecanases and inflammation-inducible cytokines (interleukin-1R and tumor necrosis factor-R) and cyclooxygenase-2 [93]. This work involving the therapeutic use of stearidonic acid and eicosapentaenoic acid derived from U. pinnatifida, support the claims that the algae can be used as a remedy for inflammation related symptoms, however further investigation is required to establish its efficacy [94].…”
Section: Polyunsaturated Fatty Acids (Pufa)supporting
confidence: 51%
“…Supplementing with 50-100 µg/mL omega-3 PUFAs, reduces the expression and activity of aggrecanases and inflammation-inducible cytokines (interleukin-1R and tumor necrosis factor-R) and cyclooxygenase-2 [93]. This work involving the therapeutic use of stearidonic acid and eicosapentaenoic acid derived from U. pinnatifida, support the claims that the algae can be used as a remedy for inflammation related symptoms, however further investigation is required to establish its efficacy [94].…”
Section: Polyunsaturated Fatty Acids (Pufa)supporting
confidence: 51%
“…Curtis et al recently showed that supplementation with PUFA caused abrogation of cytokine-induced mediators of inflammation and enzymes of matrix degradation in bovine monolayer cultures (18) and reduced expression of mRNA for ADAMTS-4, MMP-13, and MMP-3 in human osteoarthritic cartilage explants (3). These fatty acids are natural ligands for PPAR␣ and PPAR␥, both of which have been shown by us and others to be expressed in cartilage of different species (11,19).…”
Section: Discussionmentioning
confidence: 99%
“…Long-chain unsaturated fatty acids inhibit the expression and activity of aggrecanases (17). They bind to serine proteinases such as neutrophil elastase (18,19) and plasmin (20,21) and modulate their catalytic activities.…”
Section: Matrix Metalloproteinases (Mmps)mentioning
confidence: 99%