N-3 long-chain polyunsaturated fatty acids and risk of all-cause mortality among general populations: a meta-analysis

Chen, Guo‐Chong; Yang, Jing; Eggersdorfer, Manfred; Zhang, Weiguo; Qin, Li–Qiang

doi:10.1038/srep28165

Cited by 48 publications

(31 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…n -3 PUFAs can be found in foods like fish, fish oil, marine sources, flaxseed, nuts, and eggs [99]. n -3 PUFAs intake also can boost mood [101], modulate the magnitude of inflammatory responses to stressors [102], and reduce the risks of cardiovascular disease, cancer [103, 104], and all-cause mortality [105]. Insights into mechanisms that may contribute to the beneficial health effects of n -3 PUFAs can be gleaned by reviewing recent work by Kiecolt-Glaser et al [106], showing that n -3 PUFAs supplementation positively impacted cell aging, thereby highlighting how inflammation, oxidative stress, and immune cell aging—which appear to be important mechanisms prior to disease onset—that may be ameliorated through nutritional interventions.…”

Section: Dietary Factors and Nutrition In Breast Cancer Riskmentioning

confidence: 99%

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

Seiler

Chen

Brown

et al. 2018

Curr Breast Cancer Rep

100

View full text Add to dashboard Cite

Purpose of Review To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk. Recent Findings Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality. Summary Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.

show abstract

Section: Dietary Factors and Nutrition In Breast Cancer Riskmentioning

confidence: 99%

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

Seiler

Chen

Brown

et al. 2018

Curr Breast Cancer Rep

100

View full text Add to dashboard Cite

show abstract

“…The double bond closest to the methyl (ω) end of a fatty acid, usually three or six carbons, differentiates LC‐PUFAs into ω 3 or ω 6 classes, respectively. Evidence suggests consuming LC‐PUFAs in adequate amounts with a balanced ratio among LC‐PUFAs is essential for human physical and mental health (Chen et al ., ), while current diets are often low in ω 3 LC‐PUFAs.…”

Section: Introductionmentioning

confidence: 99%

A toolkit for Nannochloropsis oceanica CCMP1779 enables gene stacking and genetic engineering of the eicosapentaenoic acid pathway for enhanced long‐chain polyunsaturated fatty acid production

Poliner

Pulman

Zienkiewicz

et al. 2017

Plant Biotechnology Journal

128

105

View full text Add to dashboard Cite

Summary Nannochloropsis oceanica is an oleaginous microalga rich in ω3 long‐chain polyunsaturated fatty acids (LC‐PUFAs) content, in the form of eicosapentaenoic acid (EPA). We identified the enzymes involved in LC‐PUFA biosynthesis in N. oceanica CCMP1779 and generated multigene expression vectors aiming at increasing LC‐PUFA content in vivo. We isolated the cDNAs encoding four fatty acid desaturases (FAD) and determined their function by heterologous expression in S. cerevisiae. To increase the expression of multiple fatty acid desaturases in N. oceanica CCMP1779, we developed a genetic engineering toolkit that includes an endogenous bidirectional promoter and optimized peptide bond skipping 2A peptides. The toolkit also includes multiple epitopes for tagged fusion protein production and two antibiotic resistance genes. We applied this toolkit, towards building a gene stacking system for N. oceanica that consists of two vector series, pNOC‐OX and pNOC‐stacked. These tools for genetic engineering were employed to test the effects of the overproduction of one, two or three desaturase‐encoding cDNAs in N. oceanica CCMP1779 and prove the feasibility of gene stacking in this genetically tractable oleaginous microalga. All FAD overexpressing lines had considerable increases in the proportion of LC‐PUFAs, with the overexpression of Δ12 and Δ5 FAD encoding sequences leading to an increase in the final ω3 product, EPA.

show abstract

“…There have been several interesting observational studies that investigated the relationships between dietary or circulating n-3 LCPUFAs and all-cause mortality, and these have recently been assessed by a systematic review and meta-analysis that included 11 prospective observational studies [29]. The studies included 371,965 participants from general populations and considered 31,185 death events.…”

Section: What Do Observational Studies Tell Us About Dha and Ara In Ementioning

confidence: 99%

“…From this analysis, the dose-response indicated that for each 0.3 g/day increment in n-3 LCPUFA intake, there was an associated 6% lower risk of all-cause mortality and for each 1% increment in the proportions of circulating DHA and EPA in total fatty acids in blood there was an associated 21 and 20% decreased risk of all-cause mortality respectively. Moderate to high heterogeneity was observed across the analysis, but the authors concluded that the findings suggest that both dietary and circulating LCPUFA are inversely associated with all-cause mortality [29]. …”

Section: What Do Observational Studies Tell Us About Dha and Ara In Ementioning

confidence: 99%

Dietary Docosahexaenoic Acid and Arachidonic Acid in Early Life: What Is the Best Evidence for Policymakers?

Forsyth¹,

Calder²,

Zotor³

et al. 2018

Ann Nutr Metab

View full text Add to dashboard Cite

Background: A wealth of information on the functional roles of docosahexaenoic acid (DHA) and arachidonic acid (ARA) from cellular, animal, and human studies is available. Yet, there remains a lack of cohesion in policymaking for recommended dietary intakes of DHA and ARA in early life. This is predominantly driven by inconsistent findings from a relatively small number of randomised clinical trials (RCTs), which vary in design, methodology, and outcome measures, all of which were conducted in high-income countries. It is proposed that this selective evidence base may not fully represent the biological importance of DHA and ARA during early and later life and the aim of this paper is to consider a more inclusive and pragmatic approach to evidence assessment of DHA and ARA requirements in infants and young children, which will allow policymaking to reflect the marked diversity of need worldwide. Summary: Data from clinical RCTs is considered in the context of the extensive evidence from experimental, animal and human observational studies. Although the RCT data shows evidence of beneficial effects on visual function and in specific cognitive domains, early methodological approaches do not reflect current thinking and this undermines the strength of evidence. An outline of a framework for an inclusive and pragmatic approach to policy development on dietary DHA and ARA in early life is described. Conclusion: High-quality RCTs that will determine long-term health outcomes in appropriate real-world settings need to be undertaken. In the meantime, a collective pragmatic approach to evidence assessment, may allow public health policymakers to make comprehensive reasoned judgements on the merits, costs, and expediency of dietary DHA and ARA interventions.

show abstract

N-3 long-chain polyunsaturated fatty acids and risk of all-cause mortality among general populations: a meta-analysis

Cited by 48 publications

References 51 publications

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

A toolkit for Nannochloropsis oceanica CCMP1779 enables gene stacking and genetic engineering of the eicosapentaenoic acid pathway for enhanced long‐chain polyunsaturated fatty acid production

Dietary Docosahexaenoic Acid and Arachidonic Acid in Early Life: What Is the Best Evidence for Policymakers?

Contact Info

Product

Resources

About