N-3 polyunsaturated fatty acids ameliorate hepatic steatosis via the PPAR-α/CPT-1α pathway in a mouse model of parenteral nutrition

Tian, Feng; Wang, Jiwei; Sun, Haifeng; Yang, Jianbo; Wang, Peng; Wan, Songlin; Gao, Xuejin; Zhang, Li; Li, Jieshou; Wang, Xinying

doi:10.1016/j.bbrc.2018.05.095

Cited by 23 publications

(17 citation statements)

References 30 publications

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“…The expression of CPT1 was increased in the Heigai pigs fed the dietary n-6/n-3 PUFA ratio of 3:1 in SAT and LDM. This result was consistent with the previous studies that n-3 PUFA enhanced the expression of CPT1 [24]. ATGL, HSL, CPT1, and FABP4 expression are related to lipid metabolism especially lipolysis.…”

Section: Discussionsupporting

confidence: 93%

“…We also found that high n-3 PUFA and low n-6/n-3 PUFA ratio diet reduced TC and TG contents. These results were consistent with the previous findings that n-3 PUFA could help to reduce TG and TC contents [23,24]. These data suggest that high n-3 PUFA and low n-6/n-3 PUFA ratio diets could help us to produce pork meat with low TC and TG contents.…”

Section: Discussionsupporting

confidence: 92%

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Low Dietary n-6/n-3 PUFA Ratio Regulates Meat Quality, Reduces Triglyceride Content, and Improves Fatty Acid Composition of Meat in Heigai Pigs

Nong

Wang

Zhou

et al. 2020

Animals

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The objective of this study was to investigate the effects of dietary supplementation with different n-6/n-3 polyunsaturated fatty acid (PUFA) ratios on growth performance, meat quality, and fatty acid profile in Heigai pigs. A total of 54 Heigai finishing pigs (body weight: 71.59 ± 2.16 kg) were randomly divided into three treatments with six replications (three pigs per replication) and fed diets containing different n-6/n-3 PUFA ratios: 8:1, 5:1, and 3:1. Pigs fed the dietary n-6/n-3 PUFA ratio of 8:1 had the highest feed to gain ratio (p < 0.01), carcass weight (p < 0.05), redness a* (p < 0.01), and yellowness b* (p < 0.01). Fatty acid compositions in longissimus dorsi muscle (LDM) and subcutaneous adipose tissue (SAT) were significantly changed (p < 0.01). Notably, the meat from the pigs fed with the low dietary n-6/n-3 PUFA ratio had higher n-3 PUFA contents (p < 0.01) and lower n-6/n-3 PUFA ratio (p < 0.01). The triglyceride and total cholesterol contents were significantly decreased in SAT from the pigs fed with dietary n-6/n-3 PUFA ratios of 5:1 (p < 0.05) and 3:1 (p < 0.01). Reducing n-6/n-3 PUFA ratio upregulated the expression of HSL (p < 0.05), CPT1 (p < 0.01), and FABP4 (p < 0.01) but downregulated ATGL (p < 0.01) expression. These results demonstrate that the lower n-6/n-3 PUFA ratio regulates meat quality and enhances the deposition of n-3 PUFA in Heigai pigs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Low Dietary n-6/n-3 PUFA Ratio Regulates Meat Quality, Reduces Triglyceride Content, and Improves Fatty Acid Composition of Meat in Heigai Pigs

Nong

Wang

Zhou

et al. 2020

Animals

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“…In the liver, PPARα could be involved in the expression of CPT‐1α . [ 35 ] CPT‐1α is a master regulator of the lipid β‐oxidation process, which is frequently considered as a marker of lipid degradation. [ 6 ] Similarly, in adipose tissue, over expression of PPARα was reported to induce the activation of fatty acid metabolism through the expression of CPT‐1β .…”

Section: Discussionmentioning

confidence: 99%

Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

Subramanian

Shanmugamprema

Subramani

et al. 2021

Molecular Nutrition Food Res

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Occurrence of obesity and its associated metabolic disorders continues to escalate. The present study evaluates the anti-obesity effects of ethanolic fruit extract of Terminalia chebula (EETC) on high fat diet induced obese mice. The bioactive compounds present in the EETC is evaluated by Fourier-transform infrared (FT-IR), Gas chromatography-mass spectrometry (GC-MS), and Liquid chromatography-mass spectrometry (LC-MS) analysis. The effects of EETC on energy intake, glucose tolerance, and various biochemical parameters were analyzed using laboratory mice. Relative gene expression of Fatty acid synthase (FAS), Peroxisome proliferator-activated receptors (PPAR ), Carnitine palmitoyltransferase-1 (CPT-1), Tumor necrosis factor alpha (TNF-) as well as Interleukin 6 (IL-6) were analyzed in liver and adipose tissues. The findings reveal the hypolipidemic and anti-obesity potential of EETC on high fat fed obese mice. EETC exerts its anti-obesity effects by suppressing lipogenesis through reduction in lipogenic enzyme (FAS) expression, increased fatty acid oxidation via PPAR and CPT-1 and by triggering the anti-inflammatory responses. To our knowledge, this is the first report of the effect of EETC on PPAR and CPT-1 in in vivo.

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“…El Kasmi et al [6][7][8] reported that Kupffer cell activation by intestinal-derived lipopolysaccharide through Toll-like receptor 4 signaling, phytosterols from intravenous lipid emulsions, and macrophage-derived IL-1β/NF-κB signaling promotes liver injury in PNALD. Furthermore, changes in metabolic processes such as lipogenesis, triglyceride secretion, and fatty acid oxidation contribute to the occurrence and progression of PNALD [9][10][11]. Despite considerable investigation, the cause(s) and mechanism(s) of the disease remain obscure.…”

Section: Introductionmentioning

confidence: 99%

“…BioMed Research International or disease [27,28]. The low levels of omega-3 PUFA in the PN group might also provide some evidence for treating of PNALD with fish oil [9,29]. The metabolism of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) is linked to the hepatocyte secretion of very low-density lipoproteins (VLDL) comprising triglycerides, cholesterol, and phospholipids.…”

mentioning

confidence: 99%

Differential Metabolomic Analysis of Liver Tissues from Rat Models of Parenteral Nutrition-Associated Liver Disease

Wan

Yang

Mamtawla

et al. 2020

BioMed Research International

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Parenteral nutrition (PN) is a life-saving therapy for patients with intestinal failure, but parenteral nutrition-associated liver disease (PNALD) limits its long-term use. The present study is aimed at determining which pathways are altered most notably in a rat model of PNALD. We randomly assigned male Sprague-Dawley (SD) rats into two different groups, whereby they received either enteral nutrition (EN) or PN. Liver tissues were harvested from all rats 7 days later for metabolomic profiling. The composition of primary conjugated bile acids was altered, the synthesis of polyunsaturated fatty acids was reduced, the conversion of pyruvate to acetyl-CoA was blocked, and the synthesis of phosphatidylcholine was inhibited in rats with PNALD. Riboflavin, which is involved in the electron transfer process in the mitochondrial electron transport chain, was remarkably decreased in PNALD rats. A deficiency of polyunsaturated fatty acids, riboflavin, choline, and taurine might be involved in the progression of PNALD. The implications of these findings for the field of medicine are that supplementation with polyunsaturated fatty acids, riboflavin, choline, and taurine might have potential as therapeutic strategies for PNALD and also shed light on the mechanisms of PNALD.

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N-3 polyunsaturated fatty acids ameliorate hepatic steatosis via the PPAR-α/CPT-1α pathway in a mouse model of parenteral nutrition

Cited by 23 publications

References 30 publications

Low Dietary n-6/n-3 PUFA Ratio Regulates Meat Quality, Reduces Triglyceride Content, and Improves Fatty Acid Composition of Meat in Heigai Pigs

Low Dietary n-6/n-3 PUFA Ratio Regulates Meat Quality, Reduces Triglyceride Content, and Improves Fatty Acid Composition of Meat in Heigai Pigs

Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy

Differential Metabolomic Analysis of Liver Tissues from Rat Models of Parenteral Nutrition-Associated Liver Disease

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