2011
DOI: 10.1016/j.ajog.2011.01.030
|View full text |Cite
|
Sign up to set email alerts
|

N-acetyl-cysteine (NAC) attenuates LPS-induced maternal and amniotic fluid oxidative stress and inflammatory responses in the preterm gestation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

4
26
0

Year Published

2012
2012
2019
2019

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 31 publications
(30 citation statements)
references
References 31 publications
4
26
0
Order By: Relevance
“…Furthermore, treatment with NAC significantly reduced embryo loss and amniotic fluid ROS and IL-6 levels (Fig. 2a–c), which is supported by other reports showing that NAC improved survival of offspring after LPS injection in rat dams at GD16-183651, provided protection against fetal death and preterm labor induced by maternal inflammation33, and lowered the inflammatory cytokine response in amniotic fluid and placenta in rats3537. A previous publication reported that NAC has potential life-threatening effects on a fetus that has been exposed to endotoxins, which worsens LPS-induced fetal hypoxemia and hypotension52.…”
Section: Discussionsupporting
confidence: 86%
“…Furthermore, treatment with NAC significantly reduced embryo loss and amniotic fluid ROS and IL-6 levels (Fig. 2a–c), which is supported by other reports showing that NAC improved survival of offspring after LPS injection in rat dams at GD16-183651, provided protection against fetal death and preterm labor induced by maternal inflammation33, and lowered the inflammatory cytokine response in amniotic fluid and placenta in rats3537. A previous publication reported that NAC has potential life-threatening effects on a fetus that has been exposed to endotoxins, which worsens LPS-induced fetal hypoxemia and hypotension52.…”
Section: Discussionsupporting
confidence: 86%
“…Several studies have shown that markers of oxidative stress are increased during maternal inflammation. Following maternal LPS injection, elevated oxidative stress has been observed in rat fetus brains several hours and days after delivery 14,22,44,45. As previously mentioned, proinflammatory cytokines induce oxidative stress mediators.…”
Section: Measuring the Oxidative Stress Responsementioning
confidence: 80%
“…Previously, we analyzed the in vivo maternal inflammatory response 6 hours after lipopolysaccharide injection at e16 and e20,19,28,29, and the maternal proinflammatory cytokine response to lipopolysaccharide was more than twofold greater at e16 versus e20. This emphasizes that both maternal compartments and the placenta induce more proinflammatory cytokines at a preterm gestational age than at near-term.…”
Section: Discussionmentioning
confidence: 99%