N-Acetyl Cysteine Reduces Cisplatin Ototoxicity

Abstract

Objective: To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity. Materials and Methods:This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment.Results: The OAEs were attenuated in the cisplatin group: (−1.31/−4.90), (6.28/4.58), (4.00/0.93), (2.73/−3.74), (2.66/−4.53).The group that received NAC in addition to cisplatin had better OAEs.Conclusion: Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.