N-Acetyl-Cysteine Treatment after Lower Extremity Amputation Improves Areas of Perfusion Defect and Wound Healing Outcomes

Wound Healing: Cellular Review With Specific Attention to Postamputation Care

“…66 Aimed at increased angiogenesis in the proliferative phase, there is evidence that N-acetylcysteine can increase amputation stump perfusion with the goal of better long-term wound healing and more efficient scar formation. 67 Stem cell therapy, particularly employing cells from the human amniotic membrane, represents an auspicious avenue for antifibrotic treatment. Amniotic epithelial cells and amniotic mesenchymal cells, with their self-renewal and multilineage differentiation capabilities, exhibit anti-inflammatory and antifibrotic properties.…”