N-acetyl Cysteine Use in the Treatment of Shock Liver

Parvataneni, Swetha; Vemuri-Reddy, Sireesha M

doi:10.7759/cureus.7149

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…Parvataneni et al employed NAC in shock liver, contrary to the belief that NAC should not be used for shock or ischemic hepatitis. They observed positive results, and the use of NAC helped prevent the need for liver transplant [ 1 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it promotes an increase in nitrite levels, leading to vasodilation, thereby enhancing oxygen delivery to tissues. [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Viral and drug-induced acute liver injury are the most common causes; however, other potential factors include ischemic events, Budd-Chiari syndrome, autoimmune diseases, Wilson's disease, mushroom toxicity, and others. In the United States, among drug-induced causes, acetaminophen-induced ALF is the most common, for which N-acetylcysteine (NAC) is the drug of choice along with the management of complications and possible liver transplant [2,3]. In Spain, hepatitis secondary to amphetamine use ranks as the second most common form of hepatitis in individuals under the age of 25, following viral hepatitis [4].…”

Section: Introductionmentioning

confidence: 99%

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A Case Report Demonstrating the Favorable Outcomes of Using N-acetylcysteine (NAC) in Managing Hepatic Injury Induced by Amphetamine-Related Drug Toxicity: Do We Underestimate Its Potential?

Aulakh,

Singh

2024

Cureus

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A 59-year-old male with a history of alcohol abuse presented with altered mental status. Upon examination, he was hypertensive and lethargic, and laboratory results revealed severe transaminitis, coagulopathy, and lactic acidosis, despite having normal serum alcohol levels. Additionally, his urine drug screen tested positive for methamphetamine. Following the exclusion of infectious, autoimmune, and other common causes of acute hepatitis, a diagnosis of methamphetamine-induced acute hepatitis was established. A non-acetaminophen toxicity N-acetylcysteine (NAC) protocol was initiated, resulting in a positive response with improvement in mentation and a decrease in liver enzyme levels. This case emphasizes the potential effectiveness of NAC in treating amphetamine-induced liver injury, supported by the limited available literature on the subject.

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Section: Discussionmentioning

confidence: 99%

“…Additionally, it promotes an increase in nitrite levels, leading to vasodilation, thereby enhancing oxygen delivery to tissues. [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Report Demonstrating the Favorable Outcomes of Using N-acetylcysteine (NAC) in Managing Hepatic Injury Induced by Amphetamine-Related Drug Toxicity: Do We Underestimate Its Potential?

Aulakh,

Singh

2024

Cureus

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“…The analysis showed that reduced expression of NQO1, GSTP1, GSTA5, GSTM1, AKR7A1, and GCLC may also lead to decrease the level of N-acetyl-L-cysteine (NAC). NAC is GSH precursor, which increases its concentration, elevates NO levels, and provides overall anti-inflammatory activity [ 103 ]. In the study conducted by Sueck et al, the conjugated OTA-NAC metabolite was observed in human urine [ 104 ].…”

Section: The Mechanisms Responsible For Liver Damagementioning

confidence: 99%

Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention

Więckowska,

Szelenberger,

Niemcewicz

et al. 2023

Molecules

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Ochratoxin A (OTA) is considered as the most toxic of the other ochratoxins synthesized by various fungal species belonging to the Aspergillus and Penicillium families. OTA commonly contaminates food and beverages, resulting in animal and human health issues. The toxicity of OTA is known to cause liver damage and is still being researched. However, current findings do not provide clear insights into the toxin mechanism of action. The current studies focusing on the use of potentially protective compounds against the effects of the toxin are insufficient as they are mainly conducted on animals. Further research is required to fill the existing gaps in both fields (namely the exact OTA molecular mechanism and the prevention of its toxicity in the human liver). This review article is a summary of the so far obtained results of studies focusing on the OTA hepatotoxicity, its mode of action, and the known approaches of liver cells protection, which may be the base for expanding other research in near future.

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N-acetylcysteine for non-acetaminophen induced acute liver failure

Yoshida

Jiang

Hussaini

2022

Saudi Journal of Gastroenterology

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The use of N-acetylcysteine (NAC) for non-acetaminophen-induced acute liver failure (NAI-ALF) has been increasing despite controversy in its efficacy. National guidelines are in disagreement for NAC use as standard of care; however, many healthcare centers continue to adopt the use of NAC outside of acetaminophen poisoning. While NAC may have multiple mechanisms of action in treatment of ALF, this has not translated to clinical benefit. Murine models have reported antioxidant and anti-inflammatory properties, as well as improvement in liver-specific microcirculation. Multiple case studies and series have reported positive outcomes of NAC treatment for ALF of various etiologies. While prospective studies suggested the benefit of NAC treatment, these studies have methodological and statistical shortcomings that affect the validity of the results. In this review, we aimed to summarize the existing literature on the efficacy of NAC for NAI-ALF including mechanism of action, case studies and series demonstrating outcomes, and prospective studies that have led to its current widespread use, along with the reported rate of adverse events.

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N-acetyl Cysteine Use in the Treatment of Shock Liver

Cited by 3 publications

References 18 publications

A Case Report Demonstrating the Favorable Outcomes of Using N-acetylcysteine (NAC) in Managing Hepatic Injury Induced by Amphetamine-Related Drug Toxicity: Do We Underestimate Its Potential?

A Case Report Demonstrating the Favorable Outcomes of Using N-acetylcysteine (NAC) in Managing Hepatic Injury Induced by Amphetamine-Related Drug Toxicity: Do We Underestimate Its Potential?

Ochratoxin A—The Current Knowledge Concerning Hepatotoxicity, Mode of Action and Possible Prevention

N-acetylcysteine for non-acetaminophen induced acute liver failure

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