N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Silva, Milena Costa da; Silva, Henrique Nunes da; Cruz, Rita de Cássia Alves Leal; Amoah, Solomon Kweku Sagoe; Silva, Suédina Maria de Lima; Fook, Marcus Vinícius Lia

doi:10.3390/ma12111807

Cited by 22 publications

(22 citation statements)

References 87 publications

(96 reference statements)

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“…The current experiment was performed in accordance with the American Society for Testing and Materials (ASTM) D2256 (Standard Test Method for Tensile Properties of Yarns by the Single-Strand Method) [18]. In more detail, this method covers the measurement of tensile properties of monofilament, multifilament, and spun yarns, either single, plied, or cabled with the exception of yarns that stretch more than 5.0% when there is an increase in the tension from 0.05 to 1.0 cN/tex (0.5-1.0 gf/tex).…”

Section: Experimental Rationalementioning

confidence: 99%

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Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Choi¹,

Kang²,

Choi³

et al. 2019

JFB

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To date, extensive studies have been conducted to assess diverse types of sutures. But there is a paucity of data regarding biomechanical properties of commonly used suture materials. In the current experiment, we compared biomechanical properties and biocompatibility, such as tensile strength and elongation, the degree of bovine serum albumin (BSA) release, in vitro cytotoxicity and ex vivo frictional properties, between a non-absorbable elastic thread (NAT; HansBiomed Co. Ltd., Seoul, Korea) (NAT-R: NAT with a rough surface, NAT-S: NAT with a smooth surface) and the Elasticum® (Korpo SRL, Genova, Italy). The degree of tensile strength and elongation of Si threads was significantly higher in both the NAT-R and -S as compared with the Elasticum® (p < 0.05). Moreover, the degree of tensile strength and elongation of PET threads was significantly lower in both NAT-R and -S as compared with the Elasticum® (p < 0.05). Furthermore, the degree of tensile strength and elongation of braided Si/PET threads was significantly lower in NAT-S as compared with NAT-R and Elasticum® (p < 0.05). The degree of BSA release was significantly higher in the NAT-R as compared with Elasticum® and NAT-S throughout a 2-h period in the descending order (p < 0.05). The degree of cell viability was significantly higher in both NAT-R and -S as compared with Elasticum® (p < 0.05). The degree of coefficient of friction as well as the frictional force and strength was significantly higher in NAT-R as compared with NAT-S and Elasticum® (p < 0.05). NAT had a higher degree of biomechanical properties and biocompatibility as compared with Elasticum®. But further experimental and clinical studies are warranted to compare the efficacy, safety, and potential role as a carrier for drug delivery between NAT and Elasticum®.

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Section: Experimental Rationalementioning

confidence: 99%

“…Guidelines for the current experiment are applicable to straight, knotted, and looped specimens. Finally, experimental conditions include those for specimens that are (1) conditioned air; (2) wet, not immersed; (3) wet, immersed; (4) oven-dried; (5) exposed to elevated temperature; or (6) exposed to low temperature [18].…”

Section: Experimental Rationalementioning

confidence: 99%

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Choi¹,

Kang²,

Choi³

et al. 2019

JFB

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“…CS solution (4% w / v ) was prepared as previously reported [ 22 , 23 , 24 ]. In short, CS was dissolved in a lactic acid aqueous solution (0.206 mol/L), in stoichiometric relationship with CS amine groups, at constant stirring (200 rpm) at 25 ± 1 °C for 2 h. The obtained CS solution was transferred to a syringe (20 mL capacity and 1 mm diameter outlet tip) for subsequent wet spinning.…”

Section: Methodsmentioning

confidence: 99%

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

Silva

Santos

et al. 2020

Polymers

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This study aimed to develop meshes from the weaving of mono- and multifilament wet-spun chitosan (CS), for possible biomedical applications. In the wet-spinning process, CS solution (4% w/v) was extruded in a coagulation bath containing 70% sodium hydroxide solution (0.5 M), and 30% methanol was used. The multifilament thread was prepared by twisted of two and three monofilaments. CS threads obtained were characterized by tensile tests and scanning electron microscopy (SEM). Moreover, it was verified from the morphological tests that threads preserve the characteristics of the individual filaments and present typical “skin-core” microstructure obtained by wet spinning. CS woven meshes obtained were evaluated by optical microscopy (OM), tensile test, swelling degree, and in vitro enzymatic biodegradation. Mechanical properties, biodegradation rate, and amount of fluid absorbed of CS woven meshes were influenced by thread configuration. Hydrated CS meshes showed a larger elastic zone than the dry state. Therefore, CS woven meshes were obtained with modular properties from thread configuration used in weaving, suggesting potential applications in the biomedical field, like dressings, controlled drug delivery systems, or mechanical support.

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“…In vitro release data were analyzed by zero-order (Equation 7), Higuchi (Equation (8)), and Peppas-Sahlin (Equation (9)) kinetic models [71][72][73][74][78][79][80], using the DDSolver [75], an add-in program for modeling and comparison of drugs [81]. This study was carried out to investigate the mechanism of dexamethasone (DEX) release from CS and CS/HA beads, prepared into two coagulation solutions (TPP9 and TPP6).…”

Section: Release Kineticsmentioning

confidence: 99%

The Impact of the Ionic Cross-Linking Mode on the Physical and In Vitro Dexamethasone Release Properties of Chitosan/Hydroxyapatite Beads

et al. 2019

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In this study, the effect of the ionic cross-linking mode on the ability to control physical properties and in vitro release behavior of the dexamethasone (DEX) drug from chitosan (CS) and chitosan/hydroxyapatite (CS/HA) beads was investigated. CS solutions without and with HA and DEX were dripped into two coagulation solutions, prepared with a non-toxic ionic crosslinker (sodium tripolyphosphate, TPP) and distilled water, one at pH = 9.0 and other at pH = 6.0. Optical microscopy (OM) and scanning electron microscopy (SEM) results showed changes on the surface topology of the beads, with a reduction of roughness for beads prepared at pH = 6.0 and an increase for the one prepared at pH = 9.0. The diameter and sphericity of the beads prepared at pH = 6.0 proved more uniform and had a larger pore size with a good interconnectivity framework. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) suggested a higher crosslinking degree for beads prepared at pH = 6.0, corroborated by X-ray diffraction profiles (XRD) analysis that indicated a decrease in the crystalline structure for such beads. In in vitro drug release data, all beads presented a sustained release during the studied period (24 h). The drug release rate was affected by the pH of the coagulation solution used in the preparation of the beads. The in vitro kinetics of the release process was of the Peppas–Sahlin model, controlled by both diffusion and relaxation of polymer chains or swelling (anomalous transport mechanism). Our results suggest that DEX-loaded CS/HA beads, crosslinked in TPP coagulation solution at pH = 9.0, led to a decrease in the DEX release rate and prolonged the release period. Thus, this composition might have prospective as a functional material for bone and cartilage tissue engineering.

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N-Acetyl-D-Glucosamine-Loaded Chitosan Filaments Biodegradable and Biocompatible for Use as Absorbable Surgical Suture Materials

Cited by 22 publications

References 87 publications

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Biomechanical Properties and Biocompatibility of a Non-Absorbable Elastic Thread

Chitosan Woven Meshes: Influence of Threads Configuration on Mechanical, Morphological, and Physiological Properties

The Impact of the Ionic Cross-Linking Mode on the Physical and In Vitro Dexamethasone Release Properties of Chitosan/Hydroxyapatite Beads

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