N-acetyl-L-Cysteine ameliorates oxidative stress and reproductive toxicity induced by nicotine in male rats

Abstract

Background: The current study assessed the protective role of N-acetyl-L-Cysteine in alleviating the detrimental effect of nicotine on reproductive functions in male rats. Methods: twenty four adult male albino rats were divided into four groups of six rats. Control group was treated orally with 0.5ml/kg normal saline, nicotine treated group received 1.0 mg/kg of nicotine i.p, N-acetyl-L-Cysteine treated group received 100 mg/kg and 200 mg/kg i.p for four weeks. Results: Nicotine caused significant reduction in serum level of total antioxidant, testosterone and luteinizing hormone. It also caused a significant reduction in sperm count. There was impairment in testicular histology of rats treated with nicotine. N-acetyl-L-Cysteine improved the reduction in sperm count, hormone levels and testicular alterations observed in nicotine treated rats. Conclusion: The study shows that nicotine exerts significant deleterious effects on male reproductive system and the concurrent administration of N-acetyl-L-Cysteine ameliorated these detrimental effects.

Protective effect of acetylcysteine against thiamethoxam-induced hepatic and renal toxicity in rats

“…NAC, in combination with sodium bicarbonate [104] or atropine Shadnia [105] was also advised for treating humans to alleviate the negative effects of OPs, such as shortening hospital stays. In line with Abouelella, et al [106] who cited that, NAC reduces nicotine-induced oxidative stress and reproductive damage in male rats.…”

Deterioration of Cytochrome C Content and Mitochondrial Dysfunction in Brain of Male Rats after Sub-Chronic Exposure to Thiamethoxam and Protective Role of N- Acetylcysteine

“…Similarly in rat brain tissue, NAC therapy exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties against chlorpyrifosinduced neurotoxicity (Mahmoud et al, 2019). According to Abouelella et al (2018), NAC saves the reproductive system by reducing nicotine-induced oxidative stress and reproductive injury in male rats. Furthermore, Kheradmandi et al (2019) found that injecting NAC intraperitoneally with chlorpyrifos reduces the pesticide's negative effects on mice testis.…”