N-Acetylaspartate/Creatine and Choline/Creatine Ratios in the Thalami, Insular Cortex and White Matter as Markers of Hypertension and Cognitive Impairment in the Elderly

Salem, Douraı̈ed Ben; Walker, Paul; Béjot, Yannick; Aho, Serge; Tavernier, Béatrice; Rouaud, Olivier; Ricolfi, F.; Brunotte, François

doi:10.1291/hypres.31.1851

Cited by 26 publications

(32 citation statements)

References 44 publications

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“…However, in our series the NAA/Cr ratio changed with treatment outcome but not with IB. In addition, the increase of NAA/Cr in controlled hypertension points to a favorable outcome of antihypertensive treatment 22,23 and not to the expected deleterious effect of white matter disease. Therefore, we hypothesize that, beyond white matter disease, frontal NAA/Cr changes could be caused by something else.…”

Section: Discussionmentioning

confidence: 94%

“…5 Regarding the changes in frontal NAA/Cr ratio, the ratio drop in our resistant hypertensive patients is in agreement with two recent chemical-shift imaging reports involving the white matter of the centrum semiovale 21 and particular areas in the white and gray matters. 22 These studies showed decreasing NAA concentrations associated with increasing severity of disease 21 and NAA/Cr decreases in the gray matter of hypertensive patients. 22 Contrary to these results, NAA/Cr was not found to differ between treated and untreated hypertensive patients in a recent related study.…”

Section: Discussionmentioning

confidence: 95%

“…22 These studies showed decreasing NAA concentrations associated with increasing severity of disease 21 and NAA/Cr decreases in the gray matter of hypertensive patients. 22 Contrary to these results, NAA/Cr was not found to differ between treated and untreated hypertensive patients in a recent related study. 23 The different outcomes might be due to the different methods used.…”

Section: Discussionmentioning

confidence: 95%

“…In the Hannesdottir et al 23 study, NAA/Cr ratio was averaged from the ratio values across all voxels measured within a field of view of 22 cm centered in the centrum ovale, including the white and gray matters. In the other studies, the authors carried out either an absolute quantification of white matter metabolites in a similar field of view 21 or metabolite ratio measurements in very specific brain areas (insular cortex, thalami and parieto-occipital peritrigonal white matter), 22 as we did with our single-voxel analysis of the frontal lobe and the PPL. As sensitivity of metabolite ratios to abnormalities has been reported to be less than absolute quantification, 24 the added effects of different quantification methods and differences in the regions of interest possibly accounted for the conflicting results.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the originality of these results also dwells in the sample characteristics. Although, in the other quoted papers, comparisons were carried out between groups of normal vs asymptomatic hypertensive patients, 5,22 symptomatic vs asymptomatic hypertensive patients, 21 or treated vs untreated patients, 23 we focused on the effect of medical treatment by comparing two groups of treated asymptomatic hypertensive patients with opposing outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Posterior paralimbic and frontal metabolite impairments in asymptomatic hypertension with different treatment outcomes

et al. 2009

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Hypertension is associated with cognitive decline in elderly persons. We studied asymptomatic hypertensive subjects using brain magnetic resonance (MR) spectroscopy to evaluate metabolite impairments before the appearance of symptoms in patients with different treatment outcomes. In all, 14 healthy controls and 37 asymptomatic hypertensive patients (17 controlled and 20 resistant) underwent brain structural MR and MR spectroscopy of the posterior paralimbic (PPL) area and left frontal white matter. Ischemic burden (IB), global cortical atrophy and microbleeds were analyzed with visual scales. Metabolite ratios involving N-acetyl-aspartate (NAA), creatine (Cr), choline (Cho) and myoinositol (mI) were computed. Ultrasound measurements, including intima-media thickness, plaques and hemodynamic ratios, were obtained. Intergroup differences in IB, atrophy and metabolite ratios, and the atrophy and IB relationship were assessed with parametric and nonparametric statistical tests. In addition, the impacts of demographic, analytic and clinical factors, ischemia and atrophy, and ultrasound measurements on metabolite ratios were assessed. The significance level was set at Pp0.05. Higher atrophy scores presented with higher total or frontal IB (Po0.05). However, there was no intergroup difference in atrophy and IB. PPL mI/Cr was increased in resistant hypertension (Po0.021), whereas frontal NAA/Cr (Po0.007) showed opposite trends between controlled (increased ratios) and resistant (decreased ratios) hypertension. Unlike PPL mI/Cr, frontal NAA/Cr showed significant correlations with the lipid profile and ultrasound measurements. PPL mI/Cr increases in resistant hypertension, and frontal NAA/Cr diverges between controlled and resistant hypertension before physical and neuropsychological symptoms appear.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Posterior paralimbic and frontal metabolite impairments in asymptomatic hypertension with different treatment outcomes

et al. 2009

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Hydrogen‐rich water and caffeine for alertness and brain metabolism in sleep‐deprived habitual coffee drinkers

Todorović

Zanini

Štajer

et al. 2021

Food Science & Nutrition

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Molecular hydrogen (dihydrogen, H 2 ) is a novel biotherapeutic gas that appears effective in various health conditions. Hydrogen-rich water (HRW: also known as hydrogen-infused water) emerges as the most common vehicle to deliver dihydrogen in biomedicine, and over 1,500 studies published during the past decade or so confirm the favorable effects of drinking HRW in both animal and human trials (for a detailed review see Yang et al., 2020). Due to its pleiotropic biological activity and ability to easily cross the blood-brain barrier

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Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review

Choi

Iordanishvili

Shah

et al. 2021

Human Brain Mapping

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A large body of molecular and neurophysiological evidence connects synaptic plasticity to specific functions and energy metabolism in particular areas of the brain. Furthermore, altered plasticity and energy regulation has been associated with a number of neuropsychiatric disorders. A favourable approach enabling the modulation of neuronal excitability and energy in humans is to stimulate the brain using transcranial direct current stimulation (tDCS) and then to observe the effect on neurometabolites using magnetic resonance spectroscopy (MRS). In this way, a well-defined modulation of brain energy and excitability can be achieved using a dedicated tDCS protocol to a predetermined brain region. This systematic review was guided by the preferred reporting items for systematic reviews and meta-analysis and summarises recent literature studying the effect of tDCS on neurometabolites in the human brain as measured by proton or phosphorus MRS. Limitations and recommendations are discussed for future research. The findings of this review provide clear evidence for the potential of using tDCS and MRS to examine and understand the effect of neurometabolites in the in vivo human brain.

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N-Acetylaspartate/Creatine and Choline/Creatine Ratios in the Thalami, Insular Cortex and White Matter as Markers of Hypertension and Cognitive Impairment in the Elderly

Cited by 26 publications

References 44 publications

Posterior paralimbic and frontal metabolite impairments in asymptomatic hypertension with different treatment outcomes

Posterior paralimbic and frontal metabolite impairments in asymptomatic hypertension with different treatment outcomes

Hydrogen‐rich water and caffeine for alertness and brain metabolism in sleep‐deprived habitual coffee drinkers

Magnetic resonance spectroscopy with transcranial direct current stimulation to explore the underlying biochemical and physiological mechanism of the human brain: A systematic review

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