N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm

Leite, Bruna; Gomes, Fernanda; Melo, Poliana de Castro; Souza, Clóvis Wesley Oliveira de; Teixeira, P.; Oliveira, Rosário; Pizzolitto, Elisabeth Loshchagin

doi:10.4322/rbeb.2013.019

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…The potential for HMOs to serve as stimulants for biofilm production was not, however, addressed in the McGuire and Bode study. As a result, we elected to investigate the effects of HMOs on S. aureus growth and biofilm production when the bacteria were treated with a combination of HMOs and a known S. aureus biofilm inhibitor, N -acetylcysteine (Ac-Cys-OH, NAC). − Initial screens were performed to determine both minimum inhibitory concentrations (MICs) of NAC against S. aureus and patterns of biofilm formation in the presence of sub-MIC concentrations of NAC. In both THB and THB + 1% glucose, the MIC was determined to be 8 mg/mL (Figures S49 and S51).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii

et al. 2017

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In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii

et al. 2017

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“…Regardless of the mechanism of action, the antibiofilm activity of NAC may be significantly reduced. Therefore, in many cases, antibiofilm treatment by NAC should be supported by the additional activity of antibiotics, silver and gold nanoparticles or other antimicrobials [17,18,19,20,21]. Another strategy could be the incorporation of NAC into the structure of larger macromolecules, thereby limiting enzymatic degradation.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm N-acetyl-L-cysteine Grafted Siloxane Polymers with Potential for Use in Water Systems

Kręgiel

Rygała

Kolesińska

et al. 2019

IJMS

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Antibiofilm strategies may be based on the prevention of initial bacterial adhesion, the inhibition of biofilm maturation or biofilm eradication. N-acetyl-L-cysteine (NAC), widely used in medical treatments, offers an interesting approach to biofilm destruction. However, many Eubacteria strains are able to enzymatically decompose the NAC molecule. This is the first report on the action of two hybrid materials, NAC-Si-1 and NAC-Si-2, against bacteria isolated from a water environment: Agrobacterium tumefaciens, Aeromonas hydrophila, Citrobacter freundii, Enterobacter soli, Janthinobacterium lividum and Stenotrophomonas maltophilia. The NAC was grafted onto functional siloxane polymers to reduce its availability to bacterial enzymes. The results confirm the bioactivity of NAC. However, the final effect of its action was environment- and strain-dependent. Moreover, all the tested bacterial strains showed the ability to degrade NAC by various metabolic routes. The NAC polymers were less effective bacterial inhibitors than NAC, but more effective at eradicating mature bacterial biofilms.

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Investigating Biofilm Formation and Antibiofilm Activity Using Real Time Cell Analysis Method in Carbapenem Resistant Acinetobacter baumannii Strains

Temel

Eraç

2022

Curr Microbiol

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N-acetylcysteine and vancomycin alone and in combination against staphylococci biofilm

Cited by 4 publications

References 37 publications

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii

Antimicrobial and Antibiofilm N-acetyl-L-cysteine Grafted Siloxane Polymers with Potential for Use in Water Systems

Investigating Biofilm Formation and Antibiofilm Activity Using Real Time Cell Analysis Method in Carbapenem Resistant Acinetobacter baumannii Strains

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