N-acetylcysteine attenuates atherosclerosis progression in aging LDL receptor deficient mice with preserved M2 macrophages and increased CD146

N-Acetylcysteine and Atherosclerosis: Promises and Challenges

“…A recent study, using an aging LDLR −/− mouse model with a regular diet, has demonstrated that NAC treatment significantly decreased aortic ROS levels and inflammatory cytokines in the serum and aortas of aging LDLR −/− mice. The same study has also shown that early and adequate NAC treatment could effectively attenuate atherosclerosis progression in aging LDLR −/− mice without extreme hyperlipidemia [59].…”

“…NAC treatment effectively prevented changes in the expressions of pro-inflammatory and anti-inflammatory cytokines, the ROS level, and macrophage polarization in the aorta of aging LDLR −/− mice. Interestingly, NAC treatment has no effect on the migration of monocytes from circulation into the aorta in aging LDLR −/− mice or on M1 population in the aorta [59].…”

Megalin-targeted acetylcysteine polymeric prodrug ameliorates ischemia-reperfusion-induced acute kidney injury

“…Recent studies have shown that NAC supplementation can have a positive effect on the prevention and improvement of a variety of diseases. For example, NAC can prevent arteriosclerosis and cardiovascular disease, diabetes, cancer, alzheimer's disease and other diseases [ [17] , [18] , [19] ]. In addition, NAC can reduce the body's damage and inflammation caused by infection, trauma, surgery and radiation therapy, and improve the quality of life and health.…”

The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3

“…N -acetylcysteine, an antioxidant that acts directly on oxygen free radicals, in this study, NAC reduced the production of oxygen free radicals caused by PGPC, suggesting that PGPC can indeed induce the production of oxygen free radicals in ECs. Additionally, studies have shown that NAC treatment for 6 months, significantly slowed the progression of atherosclerosis but did not reverse atherosclerotic lesions in aging LDLr −/− mice on a normal diet, despite the fact that the effect of antioxidants on atherosclerosis is inconsistent and occasionally contentious ( 67 ). More studies have also shown that NAC can reduce atherosclerosis ( 68 , 69 , 70 ).…”