N-acetylcysteine attenuates leukocytic inflammation and microvascular perfusion failure in critically ischemic random pattern flaps

Application of Normobaric Hyperoxygenation to an Ischemic Flap and a Composite Skin Graft

“…Their works cover a variety of physical factors and therapeutic modalities to influence with perfusion and tissue oxygen tension in relation to wound healing and postoperative infection in surgical patients. 12,14,21,22 Although there are a number of adjunct therapies for increasing the survival of vascularized flaps, including vasodilators, antioxidant drugs, 23 precursor mobilization, 24 hematopoiesis, 24,25 and cooling, 26 we have no reliable supportive treatments for nonvascularized tissue grafts. As shown in this study, systemic NBO therapy with 60% O 2 is a safe therapy and may bring significant benefits to graft survival through improving PtO 2 surrounding the recipient tissue.…”

Coexistence of IL-6 -572C/G and ICAM-1 K469E Polymorphisms among Patients with Sudden Sensorineural Hearing Loss

“…The interplay between IL-6 and ICAM-1 amplifies inflammation, which shows a negative effect on lipid metabolism and microvascular perfusion, resulting in ischemia. The I/R (ischemia/ reperfusion) injury, in turn, increases the expression of Interleukins, generates oxygen free radicals and promotes neutrophil infiltration, which can significantly contribute to microvascular perfusion failures (Bächle et al 2011;Moreira et al 2015). In addition, a study in albino guinea pigs revealed that ischemia for 30 min or longer would induce irreversible damage to cochlea (Tsuji et al 2002).…”

Effects of diammonium glycyrrhizinate on random skin flap survival in rats: An experimental study

“…Bächle et al (27) found that inflammation had an adverse effect on ischemic random-pattern flaps. Previous works demonstrated that NF-κB is a key molecule in the initiation P<0.05 vs. group II.…”