2018
DOI: 10.1016/j.bbadis.2017.10.027
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N-acetylcysteine effects on a murine model of chronic critical limb ischemia

Abstract: During chronic limb ischemia, oxidative damage and inflammation are described. Besides oxidative damage, the decrease of tissue oxygen levels is followed by several adaptive responses. The purpose of this study was to determine whether supplementation with N-acetylcysteine (NAC) is effective in an animal model of chronic limb ischemia. Chronic limb ischemia was induced and animals were treated once a day for 30 consecutive days with NAC (30mg/kg). After this time clinical scores were recorded and soleus muscle… Show more

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Cited by 6 publications
(7 citation statements)
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“…Consequently, knowing that the beneficial effects of NAC observed in both acute lower limb ischaemia reperfusion and CLI were obtained in healthy animals, such results could not preclude efficacy in the case of hypercholesterolaemia. 5,8,9,11 Importantly, NAC still conferred muscle protection in hypercholesterolaemic mice. Indeed, in the present study, targeting oxidative stress by antioxidant administration restored mitochondrial function, in both ApoEþ/þ and ApoEe/e mice, supporting the hypothesis that antioxidant interventions would be beneficial in terms of vascular disease prevention.…”
Section: Discussionmentioning
confidence: 98%
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“…Consequently, knowing that the beneficial effects of NAC observed in both acute lower limb ischaemia reperfusion and CLI were obtained in healthy animals, such results could not preclude efficacy in the case of hypercholesterolaemia. 5,8,9,11 Importantly, NAC still conferred muscle protection in hypercholesterolaemic mice. Indeed, in the present study, targeting oxidative stress by antioxidant administration restored mitochondrial function, in both ApoEþ/þ and ApoEe/e mice, supporting the hypothesis that antioxidant interventions would be beneficial in terms of vascular disease prevention.…”
Section: Discussionmentioning
confidence: 98%
“…Targeting oxidative stress through N-acetyl cysteine (NAC) administration has been shown to confer muscle protection in the setting of CLI. 8,9 The antioxidant effect of NAC is due to its ability to act as a reduced glutathione precursor, which is a well known direct antioxidant and a substrate of several antioxidant enzymes. Moreover, NAC can act as a direct antioxidant for some oxidant species such as nitrogen dioxide.…”
Section: Introductionmentioning
confidence: 99%
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“…56 , 57 N‐acetylcysteine as an effective antioxidant has been used to inhibit ischemia‐induced ROS formation and promote ischemic limb recovery in human subjects and mice. 58 , 59 Inhibition of ROS production with codelivery of N‐acetylcysteine has been shown to significantly increase mesenchymal stromal cell/human umbilical vein endothelial cell retention after transplantation in nondiabetic ischemic limb. 60 Furthermore, bMSCs with SOD overexpression show enhanced survival in irradiated mice, 61 and improve their therapeutic effect on myocardium infarction 62 and brain trauma.…”
Section: Discussionmentioning
confidence: 99%
“…Most of the studies regarding the effect of NAC on muscular dystrophy have been performed in the mdx model of Duchenne muscular dystrophy pathology [22,23,42,46,47], and there are few in other models. One example is an animal model of chronic limb ischemia, where NAC attenuates inflammation [48]. Another example is in a model of peripheral arterial insufficiency, where NAC improves grip strength in soleus but not extensor digitorum longus muscle [49].…”
Section: Comparison Of the Effect Of Nac In Bla/j And MDX Micementioning
confidence: 99%