N-Acetylcysteine (NAC) Inhibits Synthesis of IL-18 in Macrophage by Suppressing NLRP3 Expression to Reduce the Production of IFN-γ from NK Cells

Liu, Xiaopeng; Lu, Xufeng; Hu, Ziyi

doi:10.1155/2021/7596343

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…CS-induced lung inflammation can be attenuated by using ethanol extract from T. farfara flower buds through mediating the NLRP3 inflammasome, NF-κB and Nrf2 pathways [90]. N-Acetylcysteine has shown the potential to improve the immune state of COPD patients and a COPD animal model by downregulating pro-inflammatory and inflammatory cytokines, including IL-1β, IFN-γ, TNF-α and IL-18, through modulating and suppressing the NLRP3 inflammasome pathways of macrophages [91]. Magnesium isoglycyrrhizinate (MgIG), glycyrrhizic acid, is an anti-inflammatory agent originally used for treating hepatitis.…”

Section: Polyphenols Treatment Via Inflammasome In a Cigarette Smokin...mentioning

confidence: 99%

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Fu¹,

Kang²,

Yan³

et al. 2022

Eur Respir Rev

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COPD is predicted to become the third leading cause of morbidity and mortality worldwide by 2030. Cigarette smoking (active or passive) is one of its chief causes, with about 20% of cigarette smokers developing COPD from cigarette smoke (CS)-induced irreversible damage and sustained inflammation of the airway epithelium. Inflammasome activation leads to the cleavage of pro-interleukin (IL)-1β and pro-IL-18, along with the release of pro-inflammatory cytokines via gasdermin D N-terminal fragment membrane pores, which further triggers acute phase pro-inflammatory responses and concurrent pyroptosis. There is currently intense interest in the role of nucleotide-binding oligomerisation domain-like receptor family, pyrin domain containing protein-3 inflammasomes in chronic inflammatory lung diseases such as COPD and their potential for therapeutic targeting. Phytochemicals including polyphenols and flavonoids have phyto-medicinal benefits in CS-COPD. Here, we review published articles from the last decade regarding the known associations between inflammasome-mediated responses and ameliorations in pre-clinical manifestations of CS-COPD via polyphenol and flavonoid treatment, with a focus on the underlying mechanistic insights. This article will potentially assist the development of drugs for the prevention and therapy of COPD, particularly in cigarette smokers.

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Section: Polyphenols Treatment Via Inflammasome In a Cigarette Smokin...mentioning

confidence: 99%

Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD

Fu¹,

Kang²,

Yan³

et al. 2022

Eur Respir Rev

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“…N‐acetylcysteine (NAC) has antioxidant and anti‐inflammatory effects on COPD. Liu et al 68 have found that NAC can inhibit the expression of NLRP3 in macrophages (Figure 2 ) and reduce the production of IFN‐γ in NK cells through clinical trials. Therefore, NAC can effectively inhibit the synthesis and release of IL‐18.…”

Section: Nlrp3 and Copdmentioning

confidence: 99%

The role of the NLRP3 inflammasome in chronic inflammation in asthma and chronic obstructive pulmonary disease

Zhao

et al. 2022

Immunity Inflam & Disease

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Asthma and chronic obstructive pulmonary disease (COPD) are lung diseases characterized by airflow limitation and chronic inflammation. More and more studies have shown that the occurrence and development of asthma and COPD are related to abnormal immune responses caused by dysregulation of many genetic and environmental factors. The exact pathogenesis of the disease is still unclear. A large number of studies have shown that the NLRP3 inflammasome is involved in the process of chronic airway inflammation in asthma and COPD. Here, we summarize recent advances in the mechanism of NLRP3 inflammasome activation and regulation and its role in the pathogenesis of inflammatory lung diseases such as asthma and COPD. Meanwhile we propose possible therapeutic targets in asthma and COPD.

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“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

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confidence: 99%

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confidence: 99%