N‐acetylcysteine versus ascorbic acid or N‐acetylcysteine plus ascorbic acid in preventing contrast‐induced nephropathy: A meta‐analysis

Feng, Yan; Huang, Xing; Li, Lin; Chen, Zhi

doi:10.1111/nep.13068

Cited by 9 publications

(9 citation statements)

References 42 publications

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“…According to the mechanism of ROSpromoted development of CIN, the corresponding removal of ROS has been studied in preclinical and clinical studies. Sodium bicarbonate [46], n-acetylcysteine (NAC) [47], theophylline [48,49], dopamine [50], furosemide [51], mannitol [52], and ascorbic acid [53] have been studied in the clinical prevention of CIN. In preclinical studies, the protective effects of melatonin [54], tocopherol [55,56], and L-carnitine [57] have also been studied with regard to CIN.…”

Section: International Journal Of Polymer Sciencementioning

confidence: 99%

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Dai

Zhou

Jiang

et al. 2019

International Journal of Polymer Science

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Contrast-induced nephropathy (CIN) is a common complication in patients with coronary arteriography, and oxidative stress is involved in the CIN pathogenesis. Sargassum fusiforme (SF) is a brown seaweed with medicinal value, and its polysaccharides have good antioxidant activity. In this study, the crude polysaccharides (cSFP-C) were extracted by cold water, precipitated by ethanol, purified by CaCl2, and detected with high contents of sulfate radical and fucose. cSFP-C is composed of glucose, glucuronic acid, xylose, rhamnose, mannose, galactose, and fucose with a molar ratio of 1.0 : 0.4 : 5.6 : 1.2 : 1.7 : 12.3 : 56.1. The cSFP-C has the typical absorption of polysaccharides. Antioxidation assays in vitro showed that cSFP-C exhibited superoxide radical scavenging activity which was better than the hot water-extracted crude polysaccharides (cSFP-H). 20 rats were divided into 4 groups (n=5): sham group; CIN group; CIN+cSFP-C group, and cSFP-C group. The CIN+cSFP-C group and cSFP-C group were pretreated intragastrically with cSFP-C at a dose of 9.45 g/kg twice daily for 5 consecutive days. Then, the CIN group and CIN+cSFP-C group were given indomethacin to develop CIN. The in vivo results showed that cSFP-C could decrease blood creatinine and urea nitrogen, inhibiting pathological injury in the renal tissues. The MDA content of renal tissues was decreased, while the activity of SOD was increased. The crude sulfated polysaccharides extracted from S. fusiforme have a renoprotective effect on oxidative stress to alleviate the kidney injury in CIN rats.

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Section: International Journal Of Polymer Sciencementioning

confidence: 99%

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Dai

Zhou

Jiang

et al. 2019

International Journal of Polymer Science

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“…They concluded that there was significant reduction in serum creatinine level after administration of NAC. 7 Some studies have provided evidence for a dose-dependent effect of NAC with more benefits observed when double doses (1,200 mg IV) of NAC were administered to reduce CIN. 8,9 Further, a meta-analysis on NAC for the prevention of CIN indicates that high-dose NAC may decrease the incidence of CIN.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Benefits of N-Acetylcysteine in the Management of Contrast-Induced Nephropathy

Velusamy,

Parthasarathy,

Jayakumar

et al. 2024

Journal of Health and Allied Sciences NU

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Objective This study aimed to assess the beneficial effects of N-acetylcysteine (NAC) in the treatment of contrast-induced nephropathy (CIN). Materials and Methods A prospective study was conducted in the department of cardiology of a tertiary health care hospital. A sample of 100 patients who had developed CIN through coronary angioplasty were categorized into two groups: one group treated with intravenous fluids (IVF) monotherapy and the other group treated with the combination of IVF and NAC therapy. Statistical Analysis The data were analyzed using statistical software SPSS software version 26 and statistical significance was set at p < 0.05. Independent t-test and paired t-test were used to analyze the parameters. Results The rate of incidence of CIN was found to be 10%. We observed that the IVF + NAC combination therapy significantly decreases the serum creatinine compared to IVF monotherapy (p = 0.004). Both therapies show similar treatment outcomes with no significant difference (p = 0.556) in the case of estimated glomerular filtration rate (eGFR). Based on creatinine clearance, the results show adding NAC does not impact any additional benefits (p = 000). The duration of hospital stay of the NAC group was reduced significantly (p = 0.000). Conclusion At present, we found that the treatment outcomes which we analyzed based on factors such as serum creatinine, eGFR, and creatinine clearance, are too inconsistent to conclude the beneficial effect of NAC in the management of CIN.

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“…Second, malnutrition can affect the body's ability to maintain fluid balance (34), which is important for sustaining adequate renal perfusion during imaging procedures that involve contrast dyes. Third, because certain micronutrients, such as vitamins C and E, have been shown to be protective against CIN (35,36), deficiencies of these nutrients in diet may predispose to this disorder. Fourth, a retrospective study involving 2,989 patients with cardiovascular disease reported a higher proportion of individuals with estimated glomerular filtration rate (eGFR) <60 min/mL in those with a low lean mass index compared to those with a high index (37), implicating a potential correlation between a low muscularity and Pooled incidence of contrast-induced nephropathy following coronary angiography or percutaneous coronary intervention.…”

Section: Discussionmentioning

confidence: 99%

Association of prognostic nutritional index with risk of contrast induced nephropathy: A meta-analysis

Chang

Sun

et al. 2023

Front. Nutr.

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BackgroundAlthough prognostic nutritional index (PNI) has been frequently applied in patients with malignancy or those during postoperative recovery, whether it is also an optimal indicator of the risk of contrast-induced nephropathy (CIN) in patients receiving coronary angiography remains uncertain. This meta-analysis aimed at investigating the clinical association of PNI with the risk of CIN in patients receiving coronary angiography or percutaneous coronary intervention.MethodsEmbase, Medline, Cochrane Library, and Google scholar were searched for studies until January 2023. The relationship between CIN risk and PNI (i.e., low vs. high) (primary outcome) as well as other variables (secondary outcomes) were analyzed using a random-effects model.ResultsOverall, 10 observational studies with 17,590 patients (pooled incidence of CIN: 18%) were eligible for analysis. There was a higher risk of CIN in patients with a low PNI compared to those with a high PNI [odd ratio (OR) = 3.362, 95% confidence interval (CI): 2.054 to 5.505, p < 0.0001, I2 = 89.6%, seven studies, 12,972 patients, certainty of evidence: very low]. Consistently, a lower PNI was noted in patients with CIN compared to those without (Mean difference = −5.1, 95% CI: −6.87 to −3.33, p < 0.00001, I2 = 96%, eight studies, 15,516 patients, certainty of evidence: very low). Other risks of CIN included diabetes and hypertension, while male gender and the use of statins were associated with a lower risk of CIN. Patients with CIN were older, had a higher creatinine level, and received a higher contrast volume compared to those without. On the other hand, pre-procedural albumin, estimated glomerular filtration rate, ejection fraction, hemoglobin, lymphocyte ratio were found to be lower in patients with CIN than in those without.ConclusionThis meta-analysis highlighted an inverse association of PNI with the risk of CIN, which required further studies for verification.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42023389185].

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N‐acetylcysteine versus ascorbic acid or N‐acetylcysteine plus ascorbic acid in preventing contrast‐induced nephropathy: A meta‐analysis

Cited by 9 publications

References 42 publications

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Characterization of Polysaccharides Extracted from Sargassum fusiforme and Its Effective Prevention of Contrast-Induced Nephropathy via Enhancing Antioxidant Capacity

Therapeutic Benefits of N-Acetylcysteine in the Management of Contrast-Induced Nephropathy

Association of prognostic nutritional index with risk of contrast induced nephropathy: A meta-analysis

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