N-Acetylglucosamine suppress collagenases activation in ultraviolet B-irradiated human dermal fibroblasts: Involvement of calcium ions and mitogen-activated protein kinases

Hwang, Yong Pil; Kim, Hyung Gyun; Han, Eun Hee; Choi, Jae Ho; Park, Bong Hwan; Jung, Kyung Hwa; Shin, Young Chul; Jeong, Hye Gwang

doi:10.1016/j.jdermsci.2011.04.008

Cited by 27 publications

(25 citation statements)

References 46 publications

(60 reference statements)

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“…Our data, indicating that KN93, a specific inhibitor of CaMKII, reduced the UVB-induced hyaluronan synthesis clearly more than its inactive control compound, suggest the involvement of calcium-related pathways in the hyaluronan response. This would be in agreement with previous reports that perturbation of epidermal calcium homeostasis is associated with changes in hyaluronan synthesis (81) and that UV radiation can activate CaMKII (60,61). There are, however, no previous reports connecting CaMKII to the regulation of Has expression.…”

Section: Dose Dependence Of the Uvb-induced Changes In Hyaluro-supporting

confidence: 92%

“…Calcium Signals Involved in the UVB-induced Hyaluronan Synthesis-UVB has been reported to increase Ca 2ϩ flux into the cytosol, activating the production of ROS (80) and various signaling cascades (61). Our data, indicating that KN93, a specific inhibitor of CaMKII, reduced the UVB-induced hyaluronan synthesis clearly more than its inactive control compound, suggest the involvement of calcium-related pathways in the hyaluronan response.…”

Section: Dose Dependence Of the Uvb-induced Changes In Hyaluro-mentioning

confidence: 59%

“…Because UV radiation has been shown to activate CaMKII by regulating intracellular calcium levels in immune cells and fibroblasts (60,61), and CaMKII can control various signaling pathways, including MAPKs, we tested the effect of a specific CaMKII inhibitor, KN93, on hyaluronan synthesis in REK cells (Fig. 4A).…”

Section: Uvb Treatment Causes Up-regulation Of All Has Isoforms-mentioning

confidence: 99%

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Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Rauhala

Hämäläinen

Salonen

et al. 2013

Journal of Biological Chemistry

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Background: Accumulation of epidermal hyaluronan is an early event in UVB-induced squamous cell carcinomas. Results: UVB increases keratinocyte hyaluronan synthesis by up-regulating hyaluronan synthases Has1 and -2 via p38 and Has3 via Ca 2ϩ /calmodulin-dependent protein kinase II (CaMKII) signaling. Conclusion: UVB triggers deposition of epidermal hyaluronan through at least two signaling pathways. Significance: Increased hyaluronan synthesis is an inherent feature of keratinocyte adaptation to radiation injury.

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Section: Dose Dependence Of the Uvb-induced Changes In Hyaluro-supporting

confidence: 92%

Section: Dose Dependence Of the Uvb-induced Changes In Hyaluro-mentioning

confidence: 59%

Section: Uvb Treatment Causes Up-regulation Of All Has Isoforms-mentioning

confidence: 99%

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Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Rauhala

Hämäläinen

Salonen

et al. 2013

Journal of Biological Chemistry

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“…35 Hwang et al reported that GlcNAc reduced reactive oxygen species formation, and MMP1 and MMP13 activity in UV-B irritated human dermal fibroblasts. 36 Furthermore, Shikhman et al showed that GlcNAc has chondroprotective and chondroinductive effects in an in vivo model of OA. 37 However, these previous studies were performed at concentrations significantly higher than the target concentrations observed in the current studies (millimolar vs. micromolar range).…”

Section: Discussionmentioning

confidence: 99%

Short-Chain Fatty Acid-Modified Hexosamine for Tissue-Engineering Osteoarthritic Cartilage

Coburn

Bernstein

et al. 2013

Tissue Engineering Part A

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“…In addition, glucosamine sulfate, inhibited UVBinduced collagen-lytic matrix metalloproteinases (MMP) production through different pathways in immortalized human skin fibroblasts. 53 Last, but not least, the antioxidants included in the dietary supplement have the property of counteracting cellular oxidative stress in different conditions. 54,55 Topical Pycnogenol ® and oral coenzyme Q10 are quite effective in preventing oxidative stress of skin ageing, 56 and Pycnogenol ® alone improved skin elasticity and hydration in women presenting dry skin, 57 reduced the hair bulbs atrophy, increased the vascular network and reduced the necrotic areas in rat incisional wound model.…”

mentioning

confidence: 99%

A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

et al. 2017

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Skin ageing involves also its annexes, such as hair and nails. Hair follicles are produced during embryogenesis. 1 In the postnatal life, hair follicle grows through three distinct phases: (i) anagen (growth) phase; (ii) catagen (regressing) phase; and (iii) telogen (resting) phase.2 This puzzling selfrenewal property is maintained by the stem cell niche located in the bulge portion of the hair follicle. 3 The hair follicle has a highly complex structure with eight distinct cell layers. The nail is hard keratin adnexa, produced by the same germinative epithelium and process through which epidermal skin cells produce the stratum corneum. Nail keratinocytes contribute to cornification through the production of hard keratins and the hardness of the nail plate is due to a high concentration of sulfur matrix protein. 4The rate of people with significant dermis and epidermis disorders increases linearly with age: at 70 years about 70% of the population claims at least one related-skin problem. 5The loss of hydration, appearance of fine wrinkles, roughness, dryness, thickening, laxity, telangiectasia, and loss of tensile strength are common features of the A B S T R A C T ORIGINAL ARTICLE ASIAN JOURNAL OF MEDICAL SCIENCESBackground: The rate of people with significant dermis and epidermis disorders increases linearly with age. The majority of skin changes are a consequence of cumulative exposure to environmental factors, such as chronic ultraviolet exposure. Aims and Objectives: Age-related dermatological changes include skin laxity, nails fragility, hair loss and hair breakage. This spontaneous, anecdotal observational study investigates if a dietary supplementation based on collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol® and coenzyme Q10 can improve age-related dermatological changes. Materials and Methods: Thirty four patients received the dietary supplement for 2 times/daily for 12 weeks. Facial skin hydration, Trans Epidermal Water Loss (TEWL) and elasticity were assessed at baseline and after 12 weeks in five selected areas. Nails hardness of the index, middle and ring fingers were also assessed at baseline and at followup by a durometer and by a nail score. The Hair Mass Index (HMI) and the Hair Breakage Index (HBI) were assessed by a mechanical device together with hair score at baseline and after 12 weeks. Results: After 12 weeks skin hydration, TEWL and elasticity significantly improved in all the tested areas (p < 0.01 and p < 0.001). Nails hardness of index, middle and ring finger significantly increased (p < 0.001) after 12 weeks. HMI and HBI were both significantly reduced (p < 0.0001) after 12 weeks. In addition, both nails and hair score improved. Conclusions: Dietary supplementation significantly improved age-related dermatological changes.

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N-Acetylglucosamine suppress collagenases activation in ultraviolet B-irradiated human dermal fibroblasts: Involvement of calcium ions and mitogen-activated protein kinases

Cited by 27 publications

References 46 publications

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling*

Short-Chain Fatty Acid-Modified Hexosamine for Tissue-Engineering Osteoarthritic Cartilage

A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study.

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