N-Alkyl Cleavage in Acid Hydrolysis of Norbornane γ-Lactams

Zalkow, L. H.; Kennedy, C. D.

doi:10.1021/jo01038a504

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, many of these ent ‐atisane diterpenoids exhibit potent bioactivity, including antiviral, antibacterial, anti‐inflammatory, and anticancer properties [1] . Over the past few decades, their fascinating chemical structures and significant bioactivities have attracted great interest from both synthetic and pharmacological communities [6–10] …”

Section: Introductionmentioning

confidence: 99%

ent‐Atisane Diterpenoids from Euphorbia helioscopia and Their Anti‐inflammatory Activities

Yang,

Wen,

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Phytochemical investigation on the anti‐inflammatory fraction extracted from the whole plant of Euphorbia helioscopia L. led to the isolation of three new ent‐atisane diterpenoids (1–3) and five known analogues (4–8). The structures and absolute configurations of the new compounds were elucidated by comprehensive analysis of the NMR, MS, IR, ECD, and X‐ray crystallography. It is worth mentioning that compound 3 belongs to a rare class of ent‐atisane diterpenoid featuring a hydroxyl group at C‐9. Bioactivity investigation showed that compounds 4, 7, and 8 exhibited significant inhibitory effects on LPS‐induced NO production in a dose‐dependent manner, which indicates their anti‐inflammatory potential.

show abstract

Section: Introductionmentioning

confidence: 99%