N-alkylated linear heptamethine polyenes as potent non-azole leads against Candida albicans fungal infections

Abstract

In this study, eighteen heptamethine dyes were synthesised and their antifungal activities were evaluated against three clinically relevant yeast species.. The eighteen dyes were placed within classes based on their core subunit i.e. 2,3,3trimethylindolenine (5a-f), 1,1,2-trimethyl-1H-benzo[e]indole (6a-f), or 2methylbenzothiazole (7a-f). The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections. This opens up the opportunity for further optimisation and investigation of this class compounds for potential antifungal treatment.

Cascade Reaction of 2-Naphthols and Azirines: One-Pot Synthesis of C-3 Naphthol-Substituted Benzo[e]indoles

“…Benzo­[ e ]­indoles as a ubiquitous heterocyclic structural motif are found in a wide array of compounds that exhibit biological activities or electro-optical properties . Notably, many valuable antifungal, antibacterial, and anticancer compounds are found to be C-3-substituted benzo­[ e ]­indole analogues .…”