N-Arylpyrazole based Scaffolds: Synthesis and biological applications

Akram, Sumayya; Jabeen, Tooba; Aslam, Sana; Yusaf, Amnah; Ahmad, Matloob; Shahid Nazir, Muhammad; Al-Hussain, Sami A.; Zaki, Magdi E.A.

doi:10.1016/j.jscs.2024.101861

Journal of Saudi Chemical Society

2024

DOI: 10.1016/j.jscs.2024.101861

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N-Arylpyrazole based Scaffolds: Synthesis and biological applications

Sumayya Akram,

Tooba Jabeen,

Sana Aslam

et al.

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2024

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Cited by 2 publications

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Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications

Akram,

Aslam,

Rasool

et al. 2024

Journal of Saudi Chemical Society

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Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications

Akram,

Aslam,

Rasool

et al. 2024

Journal of Saudi Chemical Society

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Regioselective Synthesis of N-Aryl Pyrazoles from Alkenyl Sulfoxonium Ylides and Aryl Diazonium Salts

Vishwakarma,

Sen,

Deshwal

et al. 2024

J. Org. Chem.

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A convenient and practical method has been developed for synthesizing various N-aryl pyrazoles from vinyl sulfoxonium ylides and diazonium salts. When using 1,3-disubstituted vinyl sulfoxonium ylides, the reaction selectively yields 1,3,5trisubstituted pyrazoles. On the other hand, employing 2,3-disubstituted vinyl sulfoxonium ylides results in the formation of 1,3,4trisubstituted pyrazoles. The reaction proceeds through the novel aryl diazene-derived vinyl sulfoxonium ylide. Furthermore, this method efficiently produces pyrazoles from aniline derivatives in a one-pot transformation. The reaction takes place under transition metal-free, mild conditions using easily accessible starting materials, making it a practical approach for generating pyrazoles in pharmaceutical chemistry.

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N-Arylpyrazole based Scaffolds: Synthesis and biological applications

Cited by 2 publications

References 91 publications

Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications

Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications

Regioselective Synthesis of N-Aryl Pyrazoles from Alkenyl Sulfoxonium Ylides and Aryl Diazonium Salts

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