N-Butyl Cyanoacrylate Is Very Effective for Massive Haemorrhage during the Perinatal Period

Abstract

ObjectiveThe liquid embolic agent n-butyl cyanoacrylate (NBCA) is a tissue adhesive used as an immediate and permanent embolic agent when mixed with oil-based contrast medium. In this study, the preservation of fertility with TAE using NBCA for massive haemorrhage during pregnancy or the peripartum period and the utility of this therapy were investigated.MethodsCases from January 2005 to October 2010 in which TAE was performed for massive haemorrhage in pregnant women, particularly during the peripartum period, were investigated.ResultsTAE was performed in 27 pregnant women. The embolic agent used was GS only in five cases, NBCA only in 19 cases, and additional embolization with NBCA when the effect with GS was insufficient in three cases, one each of abruptio placentae, cervical pregnancy, and uterine atony.A comparison of mean blood loss when each embolic agent was used for haemostasis showed a significant difference between cases in which GS only was used and cases in which NBCA only was used. In a comparison of mean transfusion volume, a significant difference was seen between cases in which both GS and NBCA were used and cases in which NBCA only was used. In a postoperative follow-up survey, menses resumed in eight patients, including four patients who later became pregnant and three who delivered.ConclusionsTAE with NBCA, which has an embolic effect unrelated to clotting dysfunction for massive haemorrhage during the peripartum period, is a minimally invasive and very effective treatment method for patients with severe DIC.

Successful treatment of acquired uterine arterial venous malformation using N-butyl-2-cyanoacrylate under balloon occlusion

“…reported about the possibility of uterine damage at uterine artery embolization with NBCA in comparison with gelatin sponge on the swine model ( 15 ). The pregnancy after NBCA had been shown by several reports ( 16 , 17 ). However the risk of uterine damage by NBCA has to be kelp in mind.…”

Emergency endovascular treatment of ruptured external carotid artery pseudoaneurysm caused by cervical stab wound: a case report and review of the literature

“…The use of NBCA in an animal model of hemorrhage-induced coagulopathy and various nontraumatic situations was demonstrated. [21,22] An 0.010-inch ED Coil Complex is a ready available electrical detachable coil and has a more complex outward shape and softer flexibility than conventional helical ED coils. We used these coils because the pseudoaneurysm was continuously bleeding and very fragile; coil deployment was successful.…”

High‐grade traumatic torso visceral injury with hemodynamic instability: effectiveness of transarterial embolization using n‐butyl cyanoacrylate

“…The use of gelatin sponges is popular because of their ease of handling in both traumatic and non‐traumatic clinical settings. N‐butyl cyanoacrylate is increasingly being used because of its highly penetrable liquid nature in various non‐traumatic situations . Won et al .…”