2024
DOI: 10.1126/sciadv.adp8872
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N-cadherin antagonism is bronchoprotective in severe asthma models

Nicolas L. Pereira,
Niccole Schaible,
Abhishek Desai
et al.

Abstract: Severe asthma induces substantial mortality and chronic disability due to intractable airway obstruction, which may become resistant to currently available therapies including corticosteroids and β-adrenergic agonist bronchodilators. A key effector of these changes is exaggerated airway smooth muscle (ASM) cell contraction to spasmogens. No drugs in clinical use effectively prevent ASM hyperresponsiveness in asthma across all severities. We find that N-cadherin, a membrane cell-cell adhesion protein up-regulat… Show more

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