1996
DOI: 10.1006/dbio.1996.0206
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N-Cadherin Is Involved in Myoblast Migration and Muscle Differentiation in the Avian Limb Bud

Abstract: Limb muscle formation involves invasion of the limb bud mesoderm by myogenic precursor cells from the dermomyotomes at limb bud level. Directed cell migration, homing, and differentiation of myogenic cells are controlled by the stationary cells of the limb bud mesoderm. At the level of the extracellular matrix, the molecular basis of migration control has been suggested to be exerted by the distribution of hyaluronan. Here, we demonstrate that N-cadherin-mediated interactions play a role at cell-membrane level… Show more

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Cited by 67 publications
(38 citation statements)
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“…This may be of relevance for the pathogenesis of endometriosis because several reports have indicated that N-cadherin may act as a path-finding cadherin allowing cells to be invasive and migratory in both normal development and pathophysiological processes. [71][72][73][74][75] In congruence with this idea are studies of carcinoma cells showing that invasion/metastasis requires the absence or inactivation of E-cadherin, which is often substituted by the expression of N-cadherin. 63,76 -78 Furthermore, ectopic expression of N-cadherin in differentiated, E-cadherin-positive, MCF-7 breast cancer cells switched their phenotype from noninvasive to invasive.…”
Section: Discussionmentioning
confidence: 94%
“…This may be of relevance for the pathogenesis of endometriosis because several reports have indicated that N-cadherin may act as a path-finding cadherin allowing cells to be invasive and migratory in both normal development and pathophysiological processes. [71][72][73][74][75] In congruence with this idea are studies of carcinoma cells showing that invasion/metastasis requires the absence or inactivation of E-cadherin, which is often substituted by the expression of N-cadherin. 63,76 -78 Furthermore, ectopic expression of N-cadherin in differentiated, E-cadherin-positive, MCF-7 breast cancer cells switched their phenotype from noninvasive to invasive.…”
Section: Discussionmentioning
confidence: 94%
“…N-cadherin, a type I classic cadherin initially identified in chick retina, is involved in normal cardiac and skeletal muscle development and may also be an important mediator in cartilage development and osteogenic differentiation (23)(24)(25)(26)(27). Like cadherin 11, N-cadherin is a mesenchymal cadherin.…”
Section: Discussionmentioning
confidence: 99%
“…Could N-Cadherin expressed on myoblasts and on MCT cells underlie such interactions? N-Cadherin and b-Catenin expressed in the MCT have been shown to regulate muscle patterning (Brand-Saberi et al, 1996a;Hasson et al, 2010). In addition, cadherins and b-Catenin expressed in craniofacial connective tissue play similar roles in patterning adjacent head muscles (Rinon et al, 2007), which, similar to the limb, also arise from a distinct embryonic origin.…”
Section: Perspectivesmentioning
confidence: 99%
“…In addition, cadherins and b-Catenin expressed in craniofacial connective tissue play similar roles in patterning adjacent head muscles (Rinon et al, 2007), which, similar to the limb, also arise from a distinct embryonic origin. Yet both genes are also required autonomously within the myoblasts for normal muscle development (e.g., Brand-Saberi et al, 1996a;Goichberg and Geiger, 1998;Anakwe et al, 2002Anakwe et al, , 2003Geetha-Loganathan et al, 2005Hutcheson et al, 2009). N-Cadherin has been shown to participate in homophilic interactions between neighboring cells (e.g., Levenberg et al, 1998); thus, it serves as an excellent candidate to fulfill such a role.…”
Section: Perspectivesmentioning
confidence: 99%