2022
DOI: 10.1096/fasebj.2022.36.s1.r5589
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N‐cadherin signaling stabilizes occludin tight junction via PI3K p110β signaling

Abstract: The blood‐brain barrier (BBB) is a specialized microvasculature integral for brain tissue‐fluid homeostasis that is comprised of brain endothelial cells (BECs) and pericytes. Disruption of the BBB and subsequent vascular leakage of protein‐rich fluids is toxic to surrounding neurons and is an underlying risk factor in neurodegenerative disorders. BECs and pericytes form adhesions through the transmembrane protein Neural (N)‐cadherin. Although BEC‐pericyte interactions are critical for maintaining the BBB, the … Show more

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