ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology 2023
DOI: 10.1124/jpet.122.196530
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N-cadherin Signaling via PI3Kβ-Akt3 Stabilizes Occludin Tight Junctions in the Blood-Brain Barrier

Abstract: Tight junctions (TJs) seal brain endothelial cells (BECs) to form a restrictive blood-brain barrier (BBB) to selectively control the influx of circulating substances into the central nervous system. Critical to the integrity of BBB are pericytes, cells that physically interact with BECs through Neural (N)-cadherin adhesion. Using brain samples from donors of different ages, we observed a significant loss of N-cadherin junctions in middle-aged patients. This change in N-cadherin was associated with a significan… Show more

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