N-desmethyl clozapine as purging agent of leukemic cells in vitro

Clozapine's Multiple Cellular Mechanisms: What Do We Know after More than Fifty Years? a Systematic Review and Critical Assessment of Translational Mechanisms Relevant for Innovative Strategies in Treatment-Resistant Schizophrenia

“…However, despite these preclinical observations, selective D4R antagonists failed in clinical trials (Corrigan, Gallen, Bonura, & Merchant, 2004;Kramer, Last, Getson, & Reines, 1997;Lindsley & Hopkins, 2017), thereby questioning the hypothesis that antagonism at D4Rs may play a major role in clozapine's antipsychotic action. Recently, D4R antagonists have returned to the spotlight as a novel potential therapeutic strategy for treating central nervous system (CNS) diseases (i.e., addiction and L-DOPA-induced dyskinesias in Parkinson's Disease) and cancer (Bergman & Rheingold, 2015;Dolma, et al, 2016;Huot, et al, 2015;Ratna & Sastry, 2005;Schaeffer, Pilotto, & Berg, 2014).…”